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Here, we demonstrate that non\u2010invasive and localizable pulsed electromagnetic fields (PEMFs) induce macrophage reprogramming downstream of transient receptor potential canonical 1 (TRPC1) channel activation. Brief (10\u00a0min) PEMF exposure polarized macrophages toward an M1 phenotype by activating Stimulator of Interferon Genes (STING)\u2010dependent NF\u2010\u03baB inflammatory pathways that were abolished by TRPC1 knockdown or inhibition. PEMF exposure directly enhanced the immunogenicity of breast cancer cells and modified macrophage\u2010cancer crosstalk to promote M1 macrophage polarization and the attraction of STING\u2010activated macrophages to the cancer cells. In co\u2010cultures, PEMF exposure stimulated macrophage\u2010mediated phagocytosis of cancer cells in a STING\u2010 and TRPC1\u2010dependent manner. In spheroids, PEMFs induced the reprogramming of TAMs to an M1 status and selectively enhanced infiltration of M1 macrophages, resulting in STING\u2010mediated phagocytosis of cancer cells. In mice, 2\u00a0weeks of twice\u2010weekly PEMF exposure resorbed engrafted tumors and selectively eliminated cancer cells within tumors while promoting immune cell recruitment. PEMFs offer a non\u2010invasive manner to locally reprogram TAMs within the tumor microenvironment to preferentially eliminate cancer cells.<\/jats:p>","DOI":"10.1002\/smmd.70038","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T07:26:32Z","timestamp":1780557992000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Magnetic Reprogramming of Macrophages Stimulates Phagocytosis of Breast Cancer Cells via a TRPC1\u2010STING Inflammatory Axis"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-9715-172X","authenticated-orcid":false,"given":"Viresh Krishnan","family":"Sukumar","sequence":"first","affiliation":[{"name":"NUS Centre for Cancer Research Yong Loo Lin School of Medicine National University of Singapore  Singapore"},{"name":"BICEPS Lab (Biolonic Currents Electromagnetic Pulsing Systems) National University of Singapore  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yee Kit","family":"Tai","sequence":"additional","affiliation":[{"name":"NUS Centre for Cancer Research Yong Loo Lin School of Medicine National University of Singapore  Singapore"},{"name":"BICEPS Lab (Biolonic Currents Electromagnetic Pulsing Systems) National University of Singapore  Singapore"},{"name":"Department of Surgery Yong Loo Lin School of Medicine National University of Singapore  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Nikolas","family":"Iversen","sequence":"additional","affiliation":[{"name":"BICEPS Lab (Biolonic Currents Electromagnetic Pulsing Systems) National University of Singapore  Singapore"},{"name":"Department of Surgery Yong Loo Lin School of Medicine National University of Singapore  Singapore"},{"name":"Institute for Health Innovation &amp; 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