{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T15:50:02Z","timestamp":1787327402688,"version":"build-2736575974"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T00:00:00Z","timestamp":1783728000000},"content-version":"vor","delay-in-days":40,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Smart Medicine"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The molecular mechanisms linking premature and physiological aging remain incompletely understood. Here, we present a cross\u2010species, multi\u2010organ metabolic atlas of progeroid laminopathy (PL) generated through integrated lipidomic and metabolomic profiling of heart, lung, skin, and serum from Hutchinson\u2013Gilford progeria syndrome (HGPS) mouse models and human PL cohorts. We identify organ\u2010specific metabolic alterations, with the most pronounced changes observed in the skin at the omics level. Notably, we uncover disruption of a taurine\u2013TCA\u2013TUDCA cytoprotective axis, suggesting a coordinated metabolic vulnerability in PL. Serum profiling further reveals candidate circulating biomarkers, including increased LPC(18:1e) and LysoPA along with decreased D\u2010glucose 1\u2010phosphate and NAD. These alterations are conserved across species and, importantly, display concordant trends in independent cohorts of physiologically aged healthy individuals. This overlap indicates a partial convergence between PL\u2010associated and normal aging\u2010related metabolic changes. Together, our findings provide a metabolic framework for understanding PL pathophysiology and highlight clinically accessible biomarkers that warrant future longitudinal validation.<\/jats:p>","DOI":"10.1002\/smmd.70042","type":"journal-article","created":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T07:17:13Z","timestamp":1783754233000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Metabolic Profiling Reveals Organ\u2010Specific Molecular Pathologies and Aging\u2010Associated Biomarkers in Progeroid Laminopathy"],"prefix":"10.1002","volume":"5","author":[{"given":"Lidan","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Nephrology, Children's Hospital, National Clinical Research Center for Children and Adolescents' Health and Diseases Zhejiang University School of Medicine  Hangzhou Zhejiang China"},{"name":"School of Basic Medical Sciences and Forensic Medicine Hangzhou Medical College  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Liangzhu Laboratory Zhejiang University School of Medicine  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingxian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Liangzhu Laboratory Zhejiang University School of Medicine  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Children's Hospital, National Clinical Research Center for Children and Adolescents' Health and Diseases Zhejiang University School of Medicine  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guozhen","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences and Forensic Medicine Hangzhou Medical College  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Liu","sequence":"additional","affiliation":[{"name":"Zhejiang Hospital Affiliated to Zhejiang University School of Medicine  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhan","family":"Feng","sequence":"additional","affiliation":[{"name":"Zhejiang Hospital Affiliated to Zhejiang University School of Medicine  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiazhen","family":"Yin","sequence":"additional","affiliation":[{"name":"Hangzhou Hospital of Traditional Chinese Medicine  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoyang","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Children's Hospital, National Clinical Research Center for Children and Adolescents' Health and Diseases Zhejiang University School of Medicine  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Langping","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Children's Hospital, National Clinical Research Center for Children and Adolescents' Health and Diseases Zhejiang University School of Medicine  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Children's Hospital, National Clinical Research Center for Children and Adolescents' Health and Diseases Zhejiang University School of Medicine  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Shen","sequence":"additional","affiliation":[{"name":"Liangzhu Laboratory Zhejiang University School of Medicine  Hangzhou Zhejiang 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