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The corrected four\u2010group framework includes Intact no\u2010surgery\/no\u2010injection reference knees (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a07) and 16 surgically injured knees from eight sheep assigned to Mnx (meniscectomy only,\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a04), Mnx\u00a0+\u00a0HA (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a06), or Mnx\u00a0+\u00a0HA\u00a0+\u00a0P6 (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a06). Mnx\u00a0+\u00a0HA and Mnx\u00a0+\u00a0HA\u00a0+\u00a0P6 knees received intra\u2010articular injections at Weeks 0, 1, 2, and 4. Osteochondral tissues were evaluated at Week 12 by microCT, H&amp;E scoring, and histochemical\/immunohistochemical image analysis. Endpoint\u2010specific animal\u2010 or knee\u2010level models were used, with sheep identity included as a random effect when estimable. HA\u2010based treatment was associated with favorable trabecular microCT patterns after meniscectomy. However, the primary Mnx\u00a0+\u00a0HA\u00a0+\u00a0P6 versus Mnx\u00a0+\u00a0HA contrast was not significant for percent trabecular bone volume\/BV\/TV (+1.52 percentage points; 95% CI \u22122.22 to 5.26;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.427). Histology and IHC\/histochemical findings showed selected exploratory tissue\u2010pattern signals, including collagen\u2010associated matrix staining, but did not establish consistent peptide\u2010specific superiority. These findings support cross\u2010linked HA as an intra\u2010articular biomaterial platform while defining requirements for confirmatory HA\u2010peptide hydrogel studies.\n                  <\/jats:p>","DOI":"10.1002\/smmd.70048","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T06:14:06Z","timestamp":1787638446000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Limited Added Effect of Proline\u2010Rich P6 Peptide to Cross\u2010Linked Hyaluronic Acid After Partial Lateral Meniscectomy in Sheep"],"prefix":"10.1002","volume":"5","author":[{"given":"Augustine Mark","family":"Saiz","sequence":"first","affiliation":[{"name":"Department of Biomaterials Institute of Clinical Dentistry University of Oslo  Oslo Norway"},{"name":"Department of Orthopedic Surgery UC Davis Health  Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reem","family":"Jamous","sequence":"additional","affiliation":[{"name":"Experimental Trauma Surgery Faculty of Medicine Justus Liebig University Giessen  Giessen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"St\u00f6tzel","sequence":"additional","affiliation":[{"name":"Experimental Trauma Surgery Faculty of Medicine Justus Liebig University Giessen  Giessen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5089-8693","authenticated-orcid":false,"given":"Maryam","family":"Rahmati","sequence":"additional","affiliation":[{"name":"Department of Biomaterials Institute of Clinical Dentistry University of Oslo  Oslo Norway"},{"name":"Department of Orthopedic Surgery UC Davis Health  Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard Volrath","family":"Holmboe","sequence":"additional","affiliation":[{"name":"Department of Biomaterials Institute of Clinical Dentistry University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soren David","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Biomaterials Institute of Clinical Dentistry University of Oslo  Oslo Norway"},{"name":"Department of Orthopedic Surgery UC Davis Health  Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d8ystein","family":"\u00d8vreb\u00f8","sequence":"additional","affiliation":[{"name":"Department of Biomaterials Institute of Clinical Dentistry University of Oslo  Oslo Norway"},{"name":"Regenarti AS  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"De Lauretis","sequence":"additional","affiliation":[{"name":"Department of Biomaterials Institute of Clinical Dentistry University of Oslo  Oslo Norway"},{"name":"Regenarti AS  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1187-8578","authenticated-orcid":false,"given":"Thaqif El","family":"Khassawna","sequence":"additional","affiliation":[{"name":"Experimental Trauma Surgery Faculty of Medicine Justus Liebig University Giessen  Giessen Germany"},{"name":"Faculty of Pharmacy University of Jordan  Amman Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7767-464X","authenticated-orcid":false,"given":"Liebert P.","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Oral Research Laboratory Institute of Clinical Dentistry University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Permuy","sequence":"additional","affiliation":[{"name":"Facultad de Veterinaria Universidade de Santiago de Compostela Campus Universitario  Lugo Spain"},{"name":"iBoneLab S.L.  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