{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T07:07:55Z","timestamp":1789024075065,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["92468302"],"award-info":[{"award-number":["92468302"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82330033"],"award-info":[{"award-number":["82330033"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82401376"],"award-info":[{"award-number":["82401376"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U25A2092"],"award-info":[{"award-number":["U25A2092"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52403189"],"award-info":[{"award-number":["52403189"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171153"],"award-info":[{"award-number":["82171153"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2025YFC3408803"],"award-info":[{"award-number":["2025YFC3408803"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20211012"],"award-info":[{"award-number":["BK20211012"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Smart Medicine"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The loss of spiral ganglion neurons (SGNs) and hair cells often leads to sensorineural hearing loss (SNHL), whose therapeutic effect depends on the quality and functional integrity of the residual SGNs. Compared with traditional pharmacological therapies, tissue engineering methods have been developed to provide a biomimetic environment for SGN regeneration, but static strategies and non\u2010responsive scaffolds still limit the therapy efficiency. Here, we present a composite piezoelectric nanofibrous scaffold responsive to acoustic stimulation to promote the growth of SGNs. The oriented nanofibrous scaffold comprising polyaniline (PANI), poly (L\u2010lactide) (PLLA) and gelatin was fabricated using electrospinning techniques. It was cytocompatible and provided a biomimetic culture environment with controllable electric signals for SGN regeneration. It has been confirmed that the piezoelectric nanofibrous scaffold could not only enhance cell adhesion and directional growth of SGNs, but also generate the electrical signals in response to acoustic stimulation, thereby accelerating the axon growth and functional development of SGNs. Therefore, the piezoelectric nanofibrous scaffolds could provide a new approach for SGN regeneration and a potential therapeutic strategy for SNHL.<\/jats:p>","DOI":"10.1002\/smmd.70055","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T06:58:15Z","timestamp":1789023495000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Piezoelectric Nanofibrous Scaffolds for Promoting the Growth of Spiral Ganglion Neurons via Acoustic Stimulation"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1740-4784","authenticated-orcid":false,"given":"Dongyu","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Zhongda Hospital State Key Laboratory of Digital Medical Engineering Jiangsu Provincial Key Laboratory of Critical Care Medicine School of Life Sciences and Technology School of Medicine Advanced Institute for Life and Health Southeast University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuntu","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Zhongda Hospital State Key Laboratory of Digital Medical Engineering Jiangsu Provincial Key Laboratory of Critical Care Medicine School of Life Sciences and Technology School of Medicine Advanced Institute for Life and Health Southeast University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology The First Hospital of China Medical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1842-8000","authenticated-orcid":false,"given":"Chuan","family":"Bu","sequence":"additional","affiliation":[{"name":"The Affiliated Lianyungang Hospital of Xuzhou Medical University The First People's Hospital of Lianyungang  Lianyungang China"},{"name":"The First Affiliated Hospital of Kangda College of Nanjing Medical University The First People's Hospital of Lianyungang  Lianyungang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangba","family":"He","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery School of Medicine Nanjing Tongren Hospital Southeast University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sizhe","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Zhongda Hospital State Key Laboratory of Digital Medical Engineering Jiangsu Provincial Key Laboratory of Critical Care Medicine School of Life Sciences and Technology School of Medicine Advanced Institute for Life and Health Southeast University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"Wenzhou Institute University of Chinese Academy of Sciences  Wenzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5274-8194","authenticated-orcid":false,"given":"Busheng","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery The First Affiliated Hospital of Anhui Medical University  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangnan","family":"Hu","sequence":"additional","affiliation":[{"name":"School of Medical Engineering Affiliated Zhuhai People's Hospital Beijing Institute of Technology  Zhuhai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5065-3702","authenticated-orcid":false,"given":"Huan","family":"Wang","sequence":"additional","affiliation":[{"name":"The Eighth Affiliated Hospital Sun Yat\u2010sen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3885-543X","authenticated-orcid":false,"given":"Renjie","family":"Chai","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Zhongda Hospital State Key Laboratory of Digital Medical Engineering Jiangsu Provincial Key Laboratory of Critical Care Medicine School of Life Sciences and Technology School of Medicine Advanced Institute for Life and Health Southeast University  Nanjing China"},{"name":"Co\u2010Innovation Center of Neuroregeneration Nantong University  Nantong China"},{"name":"Department of Neurology Aerospace Center Hospital School of Life Science Beijing Institute of Technology  Beijing China"},{"name":"Department of Otolaryngology Head and Neck Surgery Sichuan Provincial People's Hospital School of Medicine University of Electronic Science and Technology of China  Chengdu China"},{"name":"Southeast University Shenzhen Research Institute  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1016\/S0140-6736(21)00516-X","article-title":"Hearing Loss Prevalence and Years Lived With Disability, 1990\u20132019: Findings From the Global Burden of Disease Study 2019","volume":"397","author":"Haile L. M.","year":"2021","journal-title":"Lancet"},{"key":"e_1_2_10_3_1","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2016.94","article-title":"Congenital Hearing Loss","volume":"3","author":"Korver A. M. H.","year":"2017","journal-title":"Nature Reviews Disease Primers"},{"key":"e_1_2_10_4_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2023.102124","article-title":"Global, Regional, and National Prevalence of Hearing Loss From 1990 to 2019: A Trend and Health Inequality Analyses Based on the Global Burden of Disease Study 2019","volume":"92","author":"Jiang C. Y.","year":"2023","journal-title":"Ageing Research Reviews"},{"key":"e_1_2_10_5_1","doi-asserted-by":"crossref","first-page":"242","DOI":"10.2471\/BLT.21.285643","article-title":"The World Report on Hearing, 2021","volume":"99","author":"Chadha S.","year":"2021","journal-title":"Bulletin of the World Health Organization"},{"key":"e_1_2_10_6_1","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1146\/annurev-pharmtox-033123-114106","article-title":"Hear and Now: Ongoing Clinical Trials to Prevent Drug\u2010Induced Hearing Loss","volume":"64","author":"Lee J.","year":"2024","journal-title":"Annual Review of Pharmacology and Toxicology"},{"key":"e_1_2_10_7_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12264-025-01433-0","article-title":"Targeting Phospholipid Metabolism as an Effective Hearing Protection Strategy","volume":"42","author":"Mao H.","year":"2026","journal-title":"Neuroscience Bulletin"},{"key":"e_1_2_10_8_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.21053\/ceo.2023.01382","article-title":"Hair Cell Regeneration: From Animals to Humans","volume":"17","author":"Choi S. 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