{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:00:28Z","timestamp":1790229628137,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Smart Medicine"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Incisional hernias result from disorganized, mechanically weak scar tissue following abdominal surgery. Current surgical meshes are suboptimal and fail to guide functional regeneration, creating a critical need for new therapeutic approaches. This study introduces an architecture\u2010guided regenerative repair strategy that enhances abdominal incision repair. We developed a Hydrogel\u2010based Architecture\u2010guided Regenerative Patch (HARP) featuring 3D\u2010bioprinted, parallel\u2010aligned filaments that are oriented perpendicular to the incision to provide architectural guidance. The HARP was fabricated from a novel gelatin\/dialdehyde cellulose bioink loaded with fibroblasts and TGF\u2010\u03b21 and evaluated in vitro and in a rat abdominal incision model. In vivo, the HARP accelerated healing and yielded a twofold increase in mechanical strength over controls. This resulted from the guided deposition of a dense, anisotropic, type I collagen\u2010rich matrix that resembled native tissue. Our findings support a role for architectural guidance in functional abdominal wall repair, providing a proof of concept for a regenerative repair strategy with the potential to reduce incisional hernia risk.<\/jats:p>","DOI":"10.1002\/smmd.70056","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T05:13:08Z","timestamp":1790226788000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A 3D\u2010Bioprinted, Cell\u2010Guiding Hydrogel Patch Promotes Functional Repair of Abdominal Incisions via Anisotropic ECM Remodeling"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7365-5276","authenticated-orcid":false,"given":"Tianxing","family":"Gong","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering Shenyang University of Technology  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4793-9487","authenticated-orcid":false,"given":"Hao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Shenyang University of Technology  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6441-5663","authenticated-orcid":false,"given":"Xueqiang","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of General Surgery The Fourth Affiliated Hospital of China Medical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinwei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics General Hospital of Northern Theater Command  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Shenyang University of Technology  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiushi","family":"Tang","sequence":"additional","affiliation":[{"name":"Chinese Journal of Practical Surgery China Medical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1665-7723","authenticated-orcid":false,"given":"Stephanie","family":"Willerth","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering University of Victoria  Victoria British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7098-5090","authenticated-orcid":false,"given":"Mario","family":"Taba Junior","sequence":"additional","affiliation":[{"name":"Department of Oral &amp; Maxillofacial Surgery University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0585-297X","authenticated-orcid":false,"given":"Ricardo M.","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Department of Oral Biological and Medical Sciences University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7567-9300","authenticated-orcid":false,"given":"Hailong","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics General Hospital of Northern Theater Command  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1461-4728","authenticated-orcid":false,"given":"Shibo","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of General Surgery The Fourth Affiliated Hospital of China Medical University  Shenyang China"},{"name":"Shenyang Key Laboratory of Biomedicine and Intelligent Patch China Medical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4595-4583","authenticated-orcid":false,"given":"Hangyu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of General Surgery The Fourth Affiliated Hospital of China Medical University  Shenyang China"},{"name":"Shenyang Key Laboratory of Biomedicine and Intelligent Patch China Medical University  Shenyang China"},{"name":"Department of General Surgery The First Affiliated Hospital of Jinzhou Medical University  Jinzhou China"},{"name":"Liaoning Province\u2010Zimbabwe Belt and Road Joint Laboratory on Biomedical Data Sharing and Cancer Prevention and Control  Jinzhou Liaoning China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,23]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/B978-0-323-65381-7.00040-X","volume-title":"Plastic Surgery-Principles and Practice","author":"O\u2019neill A. C.","year":"2022"},{"key":"e_1_2_10_3_1","doi-asserted-by":"crossref","DOI":"10.3389\/jaws.2024.12452","article-title":"Incidence, Healthcare Resource Use and Costs Associated With Incisional Hernia Repair","volume":"3","author":"Smith L.","year":"2024","journal-title":"Journal of Abdominal Wall Surgery"},{"key":"e_1_2_10_4_1","first-page":"31","article-title":"Behandlung von Narbenhernien","volume":"115","author":"Dietz U. A.","year":"2018","journal-title":"Dtsch Arztebl International"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2014.12.055"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/17434440.2018.1529565"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202414724"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2012.03.009"},{"key":"e_1_2_10_9_1","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.surg.2022.12.002","article-title":"Biologic Versus Synthetic Mesh in Open Ventral Hernia Repair: A Systematic Review and Meta\u2010Analysis of Randomized Controlled Trials","volume":"173","author":"de Figueiredo S. M. P.","year":"2023","journal-title":"Surgery"},{"key":"e_1_2_10_10_1","doi-asserted-by":"crossref","DOI":"10.34133\/bmr.0031","article-title":"Recent Advances in Functional Hydrogel for Repair of Abdominal Wall Defects: A Review","volume":"28","author":"Liu Y.","year":"2024","journal-title":"Biomaterials Research"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2023.100691"},{"key":"e_1_2_10_12_1","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2103457118","article-title":"Hydrogel\u2013Mesh Composite for Wound Closure","volume":"118","author":"Gao Y.","year":"2021","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2023.100915"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2024.121942"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202305714"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c02321"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c12104"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202303836"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202315827"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202105614"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-30633-9"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ca.980050403"},{"key":"e_1_2_10_23_1","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1006\/jsre.2000.6070","article-title":"Collagen Fibers in Linea Alba and Rectus Sheaths: I. General Scheme and Morphological Aspects","volume":"96","author":"Axer H.","year":"2001","journal-title":"Journal of Surgical Research"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c04206"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44324-025-00063-4"},{"key":"e_1_2_10_26_1","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202000544","article-title":"Encapsulation of Human Natural and Induced Regulatory T\u2010Cells in IL\u20102 and CCL1 Supplemented Alginate\u2010GelMA Hydrogel for 3D Bioprinting","volume":"30","author":"Kim J.","year":"2020","journal-title":"Advanced Functional Materials"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s42242-023-00236-4"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202109864"},{"key":"e_1_2_10_29_1","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202411959","article-title":"Bio\u2010Inspired Self\u2010Healing Hydrogel for Fast Hemostasis and Accelerated Wound Healing of Gastric Ulcers","volume":"35","author":"Wen N.","year":"2024","journal-title":"Advanced Functional Materials"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28052009"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202407522"},{"key":"e_1_2_10_32_1","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.ade7880","article-title":"3D Bioprinting of Dynamic Hydrogel Bioinks Enabled by Small Molecule Modulators","volume":"9","author":"Hull S. M.","year":"2023","journal-title":"Science Advances"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2021.09.032"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2024.11.013"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtv.2009.11.004"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1013805107"},{"key":"e_1_2_10_37_1","doi-asserted-by":"crossref","DOI":"10.1098\/rsob.210356","article-title":"Functions of Exogenous FGF Signals in Regulation of Fibroblast to Myofibroblast Differentiation and Extracellular Matrix Protein Expression","volume":"12","author":"Sun C.","year":"2022","journal-title":"Open Biology"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44161-022-00043-7"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2012.07.010"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.7b00244"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-024-00716-0"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-023-00583-1"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-024-00767-3"}],"container-title":["Smart Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smmd.70056","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/smmd.70056","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smmd.70056","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T05:13:11Z","timestamp":1790226791000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/smmd.70056"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,23]]},"references-count":42,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/smmd.70056"],"URL":"https:\/\/doi.org\/10.1002\/smmd.70056","archive":["Portico"],"relation":{},"ISSN":["2751-1871","2751-1871"],"issn-type":[{"value":"2751-1871","type":"print"},{"value":"2751-1871","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,23]]},"assertion":[{"value":"2025-12-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70056"}}