{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T03:59:37Z","timestamp":1790827177270,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32201118"],"award-info":[{"award-number":["32201118"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Smart Medicine"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Chemotherapy and photothermal therapy (PTT) are recognized as effective strategies in cancer treatment. However, the challenge remains in effectively targeting these therapeutic modalities to the tumor site to improve therapeutic effects. Here, a novel hierarchical cascade\u2010activated microneedle (MN) patch (MN\n                    <jats:sub>DOX<\/jats:sub>\n                    @M\n                    <jats:sub>ICG<\/jats:sub>\n                    ) for photothermal and bioorthogonal chemotherapy was developed. The MN patch was fabricated by integrating hydrogel microspheres (M\n                    <jats:sub>ICG<\/jats:sub>\n                    ) containing tetrazine\u2010functionalized indocyanine green (Tz\u2010ICG) into the MN arrays. Upon irradiation with near\u2010infrared light, Tz\u2010ICG with high photothermal conversion efficiency can elevate the temperature of MN, facilitate PTT, and trigger the release of\n                    <jats:italic>trans<\/jats:italic>\n                    \u2010cyclooctene\u2010conjugated doxorubicin (TCO\u2010DOX) encapsulated in MN. Then, the gradually released Tz\u2010ICG from M\n                    <jats:sub>ICG<\/jats:sub>\n                    can react with TCO\u2010DOX via a specific inverse electron\u2010demand Diels\u2010Alder bioorthogonal reaction, thereby restoring the anticancer activity of DOX. Consequently, MN\n                    <jats:sub>DOX<\/jats:sub>\n                    @M\n                    <jats:sub>ICG<\/jats:sub>\n                    can efficiently eradicate tumor cells in vitro and significantly inhibit the growth of postsurgical melanoma by combining PTT with bioorthogonal chemotherapy. These findings highlight the practical value of such a hierarchical cascade\u2010activated MN patch for versatile drug delivery and biomedical applications.\n                  <\/jats:p>","DOI":"10.1002\/smmd.70059","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T03:39:46Z","timestamp":1790825986000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hierarchical Cascade\u2010Activated Microneedle Patches for Photothermal and Chemotherapy"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1786-8634","authenticated-orcid":false,"given":"Gaizhen","family":"Kuang","sequence":"first","affiliation":[{"name":"Department of Radiation and Medical Oncology Joint Centre of Translational Medicine\u2010WIUCAS The First Affiliated Hospital of Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5976-0069","authenticated-orcid":false,"given":"Wenzhao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiation and Medical Oncology Joint Centre of Translational Medicine\u2010WIUCAS The First Affiliated Hospital of Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiation and Medical Oncology Joint Centre of Translational Medicine\u2010WIUCAS The First Affiliated Hospital of Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7704-2853","authenticated-orcid":false,"given":"Qingfei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiation and Medical Oncology Joint Centre of Translational Medicine\u2010WIUCAS The First Affiliated Hospital of Wenzhou Medical University  Wenzhou China"},{"name":"School of Basic Medical Sciences Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1483-3380","authenticated-orcid":false,"given":"Hua","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Radiation and Medical Oncology Joint Centre of Translational Medicine\u2010WIUCAS The First Affiliated Hospital of Wenzhou Medical University  Wenzhou China"},{"name":"Department of Otolaryngology The Second Affiliated Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"e_1_2_10_2_1","article-title":"Cancer Statistics","volume":"76","author":"Siegel R. 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