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Herein, we report a metal\u2010free method by a complex\u2010mediated nucleophilic aromatic substitution of aryl nitriles with amines. The method can lead to rich D\u2010A type aggregation\u2010induced emission luminogens (AIEgens) with tunable properties. They emit from deep\u2010blue to yellow\u2010green and possess high photoluminescence quantum yields up to 70.5% in the aggregate state. Interestingly, the suppression of intramolecular flapping is proved to play an indispensable role in the AIE behavior, which is different from the mechanism met in other AIEgens. Moreover, the biocompatible AIEgens possess specific staining of lipid droplets in HeLa cells and the superiority of identifying fatty liver over traditional Oil Red O staining is exhibited.<\/jats:p>","DOI":"10.1002\/smo.20240039","type":"journal-article","created":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T01:15:34Z","timestamp":1731633334000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Complex\u2010mediated nucleophilic aromatic substitution with aryl nitriles to realize intramolecular flapping\u2010restricted D\u2010A AIEgens for bioimaging"],"prefix":"10.1002","volume":"3","author":[{"given":"Feng","family":"Liu","sequence":"first","affiliation":[{"name":"College of Chemistry and Materials Science Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junkai","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction The Hong Kong University of Science and Technology  Kowloon Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyi","family":"Gong","sequence":"additional","affiliation":[{"name":"School of Science and Engineering Shenzhen Institute of Aggregate Science and Technology The Chinese University of Hong Kong, Shenzhen (CUHK-SZ)  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runfeng","family":"Lin","sequence":"additional","affiliation":[{"name":"College of Chemistry and Materials Science Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyuan","family":"Qiu","sequence":"additional","affiliation":[{"name":"College of Chemistry and Materials Science Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zicheng","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Chemistry and Materials Science Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chongyang","family":"Li","sequence":"additional","affiliation":[{"name":"College of Chemistry and Materials Science Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Meng","sequence":"additional","affiliation":[{"name":"College of Chemistry and Materials Science Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijie","family":"Li","sequence":"additional","affiliation":[{"name":"Clinical Medical College of Acupuncture Moxibustion and Rehabilitation Guangzhou University of Chinese Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Tu","sequence":"additional","affiliation":[{"name":"College of Chemistry and Materials Science Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacky W. 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