{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:10:24Z","timestamp":1791288624423,"version":"4.3.0"},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T00:00:00Z","timestamp":1739750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Smart Molecules"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    With increasing drug resistance,\n                    <jats:italic>Candida<\/jats:italic>\n                    infections have posed serious threats to public health. Photodynamic therapy harnesses light to destroy pathomycete, providing a smart strategy for combating of\n                    <jats:italic>Candida<\/jats:italic>\n                    infections. However, due to lack of organelle targeting ability and bad extracellular polymeric substances penetrability, current photosensitizers (PSs) are far from desirable to clean biofilms and fight against drug resistance. Herein, a mitochondrion targeting aggregation\u2010induced emission PS, LIQ\u2010TPA\u2010TZ, was developed for the efficient photodynamic treatment of oral\n                    <jats:italic>Candida<\/jats:italic>\n                    infection. LIQ\u2010TPA\u2010TZ has good singlet oxygen and hydroxyl radical\u00a0generation ability, which can efficiently kill the\n                    <jats:italic>Candida guilliermondii<\/jats:italic>\n                    (\n                    <jats:italic>C. guilliermondii<\/jats:italic>\n                    ) and eradicate the biofilm. It not only causes mitochondrial damage by disruption of mitochondrial respiratory chain and oxidative stress\u2010related gene but also inhibits fungal adhesion and filamentous growth to prevent\n                    <jats:italic>Candida<\/jats:italic>\n                    colonization, mycelia growth and biofilm formation, which is favorable for eliminating the potential drug resistance. In the mouse oropharyngeal\n                    <jats:italic>Candida<\/jats:italic>\n                    biofilm infection model, LIQ\u2010TPA\u2010TZ significantly eliminates infection, alleviates inflammation, and accelerates mucosal defect healing. This study provides a favorable strategy for confronting drug resistance, which may be a potential Candidate for the treatment of\n                    <jats:italic>Candida<\/jats:italic>\n                    infection.\n                  <\/jats:p>","DOI":"10.1002\/smo.20240060","type":"journal-article","created":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T07:39:46Z","timestamp":1739777986000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["A mitochondria\u2010targeted aggregation\u2010induced emission photosensitizer for eradication\n                    <i>Candida<\/i>\n                    bio\ufb01lms and treating oral ulcer"],"prefix":"10.1002","volume":"3","author":[{"given":"Kun\u2010Mei","family":"Liu","sequence":"first","affiliation":[{"name":"College of Biomedical Engineering Sichuan University  Chengdu China"},{"name":"School of Life Science and Engineering Southwest Jiaotong University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Life Science and Engineering Southwest Jiaotong University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng\u2010Wei","family":"Xia","sequence":"additional","affiliation":[{"name":"School of Life Science and Engineering Southwest Jiaotong University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1602-0244","authenticated-orcid":false,"given":"Shun","family":"Feng","sequence":"additional","affiliation":[{"name":"School of Life Science and Engineering Southwest Jiaotong University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Qi","family":"Yu","sequence":"additional","affiliation":[{"name":"Asymmetric Synthesis and Chiral Technology Key Laboratory of Sichuan Province Department of Chemistry Xihua University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2047-3441","authenticated-orcid":false,"given":"Ming\u2010Yu","family":"Wu","sequence":"additional","affiliation":[{"name":"College of Biomedical Engineering Sichuan University  Chengdu China"},{"name":"School of Life Science and Engineering Southwest Jiaotong University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,17]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"604","volume":"15","author":"Crunkhorn S.","year":"2016","journal-title":"Nat. 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