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The results show that curcumin treatment alleviates ankle joint swelling, reduces inflammatory cytokines IL\u20101<jats:italic>\u03b2<\/jats:italic> and TNF\u2010<jats:italic>\u03b1<\/jats:italic>, and lowers serum uric acid concentrations. High\u2010dose curcumin notably inhibits xanthine oxidase (XOD) activity, a key enzyme in uric acid production, while it enhances the renal expression of the urate transporter ABCG2, thereby promoting uric acid excretion. Furthermore, curcumin effectively mitigates renal injury as evidenced by reduced serum creatinineand blood urea nitrogen levels and suppresses renal inflammation. At the molecular level, curcumin exerts potent antioxidant effects by lowering reactive oxygen species (ROS) levels in both cultured HK\u20102 human renal tubular epithelial cells and RAW264.7\u00a0mouse macrophages. The curcumin\u2010mediated effects are associated with the disruption of NEK7\u2010NLRP3 complex formation, leading to the suppression of the ROS\/NEK7\u2010NLRP3 inflammasome pathway. This, in turn, inhibits pyroptosis and the subsequent release of mature IL\u20101<jats:italic>\u03b2<\/jats:italic>. These findings suggest that curcumin not only reduces uric acid production but also modulates inflammation through ROS\u2010scavenging properties and its ability to inhibit the NLRP3 inflammasome.<\/jats:p>","DOI":"10.1002\/smo.20250002","type":"journal-article","created":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T05:38:05Z","timestamp":1749620285000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Curcumin ameliorates hyperuricemia and gout\u2010induced damage via modulating the ROS\u2010dependent NEK7\u2010NLRP3 inflammasome activation"],"prefix":"10.1002","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-4099-3489","authenticated-orcid":false,"given":"Zhengtian","family":"Zhao","sequence":"first","affiliation":[{"name":"State Key Laboratory of Fine Chemicals Department of Pharmaceutical Engineering School of Chemical Engineering Dalian University of Technology  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Tong","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Fine Chemicals Department of Pharmaceutical Engineering School of Chemical Engineering Dalian University of Technology  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Sun","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Fine Chemicals Department of Pharmaceutical Engineering School of Chemical Engineering Dalian University of Technology  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Lu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Fine Chemicals Department of Pharmaceutical Engineering School of Chemical Engineering Dalian University of Technology  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Fine Chemicals Department of Pharmaceutical Engineering School of Chemical Engineering Dalian University of Technology  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1108-3134","authenticated-orcid":false,"given":"Qing","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Fine Chemicals Department of Pharmaceutical Engineering School of Chemical Engineering Dalian University of Technology  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Fine Chemicals Department of Pharmaceutical Engineering School of Chemical Engineering Dalian University of Technology  Dalian China"},{"name":"Ningbo Institute of Dalian University of Technology  Ningbo China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgr.2021.01.001"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13082665"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.01464"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.3c01349"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110719"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00272.2019"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-019-0115-y"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2017.06.005"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/14397595.2021.1899569"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-018-1546-7"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.760331"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.26599\/FSHW.2022.9250181"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.108107"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2020.100889"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2024.116629"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2024.118614"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2020.607808"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.993951"},{"key":"e_1_2_9_20_1","volume":"45","author":"Siddiqui M. 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