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This operationally simple protocol enables the conversion of a broad range of aromatic alkanes into valuable ketones, including complex drug derivatives and intermediates under mild conditions using ethyl acetate as a green solvent. Mechanistic studies reveal that the reaction proceeds via a substrate\u2010oxygen charge\u2010transfer (CT) complex upon photoexcitation, generating reactive oxygen species (singlet oxygen and superoxide anion) and a key benzylic radical. Interestingly, the carbonyl product can further accelerate the transformation by participating in a separate CT complex with the starting material. To address the scalability limitations, a novel solvent\u2010free continuous\u2010flow photoreactor was developed, which demonstrated a significant efficiency enhancement of over 150\u2010fold compared to batch processes. This work presents a green, practical, and scalable method for benzylic oxidation, underpinned by a detailed mechanistic understanding of the photoinduced CT process.<\/jats:p>","DOI":"10.1002\/smo2.70058","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T04:20:46Z","timestamp":1779078046000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Visible\u2010light\u2010promoted catalyst\u2010free benzylic C\u2010H oxidation using molecular oxygen as a green oxidant"],"prefix":"10.1002","volume":"4","author":[{"given":"Jianing","family":"Li","sequence":"first","affiliation":[{"name":"Department of Pharmacy School of Chemical Engineering Dalian University of Technology  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suwen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy School of Chemical Engineering Dalian University 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