{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:42:28Z","timestamp":1792204948152,"version":"4.4.0"},"reference-count":34,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:00:00Z","timestamp":1782259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:00:00Z","timestamp":1782259200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Smart Molecules"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Photothermal therapy (PTT) has emerged as a promising minimally invasive strategy for tumor treatment due to its high selectivity, minimal drug resistance, and precise controllability. However, the efficacy of PTT is often limited by the inability of photothermal agents (PTAs) to effectively target subcellular organelles after cellular uptake. In this study, we designed and synthesized an endoplasmic reticulum (ER)\u2010targeting BODIPY\u2010based photothermal agent (ER\u2010BDP) by functionalizing a trifluoromethyl\u2010substituted BODIPY scaffold with a p\u2010toluenesulfonyl group. The resulting ER\u2010BDP nanoparticles (ER\u2010BDP NPs), co\u2010assembled with DSPE\u2010PEG\n                    <jats:sub>2000<\/jats:sub>\n                    \u2010Biotin, exhibit excellent near\u2010infrared absorption (\u03bbmax\u00a0=\u00a0780\u00a0nm), high photothermal conversion efficiency (80.3%), and efficient tumor targeting via the enhanced permeability and retention (EPR) effect. Importantly, ER\u2010BDP NPs demonstrate the ability to escape from lysosomes and specifically accumulate in the ER, where localized photothermal heating induces severe ER stress and apoptosis. In vitro and in vivo studies confirm that ER\u2010BDP NPs effectively ablate tumor cells under mild laser irradiation (760\u00a0nm, 500\u00a0mW\u00a0cm\n                    <jats:sup>\u22122<\/jats:sup>\n                    ) while showing negligible systemic toxicity. This work provides a rational design strategy for organelle\u2010targeting photothermal agents and highlights their potential for enhanced tumor therapy.\n                  <\/jats:p>","DOI":"10.1002\/smo2.70073","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T12:29:01Z","timestamp":1782304141000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A lysosomal escape\u2010enabled endoplasmic reticulum\u2010targeting BODIPY photothermal agent for enhanced tumor ablation"],"prefix":"10.1002","author":[{"given":"Shaoyang","family":"Shi","sequence":"first","affiliation":[{"name":"State Key Laboratory of Fine Chemicals Frontiers Science Center for Smart Materials Oriented Chemical Engineering Dalian University of Technology  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanbing","family":"Cao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Fine Chemicals Frontiers Science Center for Smart Materials Oriented Chemical Engineering Dalian University of Technology  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiexuan","family":"Zuo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Fine Chemicals Frontiers Science Center for Smart Materials Oriented Chemical Engineering Dalian University of Technology  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiushi","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Fine Chemicals Frontiers Science Center for Smart Materials Oriented Chemical Engineering Dalian University of Technology  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolong","family":"Zeng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Fine Chemicals Frontiers Science Center for Smart Materials Oriented Chemical Engineering Dalian University of Technology  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7777-079X","authenticated-orcid":false,"given":"Jianjun","family":"Du","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Fine Chemicals Frontiers Science Center for Smart Materials Oriented Chemical Engineering Dalian University of Technology  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4962-5186","authenticated-orcid":false,"given":"Jiangli","family":"Fan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Fine Chemicals Frontiers Science Center for Smart Materials Oriented Chemical Engineering Dalian University of Technology  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4316-5350","authenticated-orcid":false,"given":"Wen","family":"Sun","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Fine Chemicals Frontiers Science Center for Smart Materials Oriented Chemical Engineering Dalian University of Technology  Dalian China"},{"name":"Ningbo Institute of Dalian University of Technology  Ningbo China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8806-322X","authenticated-orcid":false,"given":"Xiaojun","family":"Peng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Fine Chemicals Frontiers Science Center for Smart Materials Oriented Chemical Engineering Dalian University of Technology  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202205825","volume":"19","author":"Su Z. 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