{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:20:57Z","timestamp":1790785257369,"version":"4.1.0"},"reference-count":139,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Smart Molecules"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Immune checkpoint inhibitors have transformed cancer therapy with the programmed cell death protein 1\u2013programmed death\u2010ligand 1 axis, demonstrating substantial efficacy by targeting adaptive immunity across multiple malignancies. However, the limited clinical responses observed in a considerable proportion of patients highlights the need for more effective engagement of innate immune mechanisms. In this context, the cluster of differentiation 47\u2013signal regulatory protein \u03b1 (CD47\u2013SIRP\u03b1) axis has emerged as a next\u2010generation immune checkpoint that regulates phagocytosis. CD47 is a ubiquitously expressed transmembrane glycoprotein containing an N\u2010terminal extracellular immunoglobulin variable\u2010like domain and is frequently overexpressed in both solid tumors and hematological malignancies. By binding to SIRP\u03b1 on macrophages, CD47 transmits a canonical \u201cdon't eat me\u201d signal that suppresses phagocytosis and enables tumor immune evasion. Beyond this canonical role, CD47 interacts with ligands such as thrombospondin\u20101 and integrins to regulate tumor cell migration, metabolic adaptation, and immune balance within the tumor microenvironment. Importantly, CD47 links innate immune clearance with antigen presentation and downstream adaptive immune activation, positioning it as an actionable node for next\u2010generation therapeutic designs. Although the first\u2010generation CD47 blockade has revealed challenges related to hematologic toxicity, antigen sink effects, and limited monotherapy durability, these challenges have also accelerated the development of more selective, controllable, and context\u2010responsive therapeutic strategies. In this Review, we elucidate the structural features, molecular mechanisms, pathological functions, therapeutic strategies, translational challenges, and emerging solutions of CD47, with the aim of providing a theoretical basis for overcoming current therapeutic limitations and advancing more precise cancer immunomodulatory strategies.<\/jats:p>","DOI":"10.1002\/smo2.70079","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T05:59:45Z","timestamp":1784181585000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Targeting the CD47\u2013SIRP\u03b1 phagocytic checkpoint in cancer: Biology, translational opportunities, and next\u2010generation therapeutic strategies"],"prefix":"10.1002","author":[{"given":"Ruimei","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Pharmacy Shanghai Sixth People's Hospital Affiliated Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"College of Clinical Pharmacy Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingjie","family":"Jing","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Shanghai Sixth People's Hospital Affiliated Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"College of Clinical Pharmacy Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Shanghai Sixth People's Hospital Affiliated Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"College of Clinical Pharmacy Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0762-8496","authenticated-orcid":false,"given":"Cheng","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Shanghai Sixth People's Hospital Affiliated Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"College of Clinical Pharmacy Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0279-8784","authenticated-orcid":false,"given":"Quanjun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Shanghai Sixth People's Hospital Affiliated Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"College of Clinical Pharmacy Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41571-022-00600-w","volume":"19","author":"Johnson D. B.","year":"2022","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"e_1_2_10_3_1","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1121623109","volume":"109","author":"Willingham S. B.","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"e_1_2_10_4_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41392-023-01365-z","volume":"8","author":"Liu Y.","year":"2023","journal-title":"Signal Transduction Targeted Ther."},{"key":"e_1_2_10_5_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.iotech.2022.100070","volume":"13","author":"Maute R.","year":"2022","journal-title":"Immuno\u2010Oncol. Technol."},{"key":"e_1_2_10_6_1","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2022-004589","volume":"10","author":"van Duijn A.","year":"2022","journal-title":"J. Immunother. Cancer"},{"key":"e_1_2_10_7_1","doi-asserted-by":"crossref","DOI":"10.1038\/nm.3931","volume":"21","author":"Liu X.","year":"2015","journal-title":"Nat. Med."},{"key":"e_1_2_10_8_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2009.05.046","volume":"138","author":"Jaiswal S.","year":"2009","journal-title":"Cell"},{"key":"e_1_2_10_9_1","volume":"8","author":"Ye Y.","year":"2025","journal-title":"Cancer Rep. (Hoboken)"},{"key":"e_1_2_10_10_1","doi-asserted-by":"crossref","DOI":"10.1093\/abt\/tbaa006","volume":"3","author":"Jalil A. R.","year":"2020","journal-title":"Antibody Ther."},{"key":"e_1_2_10_11_1","doi-asserted-by":"crossref","DOI":"10.1182\/blood.2024027222","volume":"145","author":"Wilde L.","year":"2025","journal-title":"Blood"},{"key":"e_1_2_10_12_1","doi-asserted-by":"crossref","DOI":"10.1093\/annonc\/mdz006","volume":"30","author":"Takimoto C. H.","year":"2019","journal-title":"Ann. Oncol."},{"key":"e_1_2_10_13_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jare.2023.10.009","volume":"63","author":"Liu Y.","year":"2024","journal-title":"J. Adv. Res."},{"key":"e_1_2_10_14_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.molcel.2008.05.026","volume":"31","author":"Hatherley D.","year":"2008","journal-title":"Mol. Cell"},{"key":"e_1_2_10_15_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.csbj.2021.09.036","volume":"19","author":"Huang B.","year":"2021","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"e_1_2_10_16_1","doi-asserted-by":"crossref","DOI":"10.1172\/JCI81603","volume":"126","author":"Weiskopf K.","year":"2016","journal-title":"J. Clin. Invest."},{"key":"e_1_2_10_17_1","doi-asserted-by":"crossref","DOI":"10.1038\/bcj.2017.7","volume":"7","author":"Pietsch E. C.","year":"2017","journal-title":"Blood Cancer J."},{"key":"e_1_2_10_18_1","doi-asserted-by":"crossref","DOI":"10.1016\/S0962-8924(00)01906-1","volume":"11","author":"Brown E. J.","year":"2001","journal-title":"Trends Cell Biol."},{"key":"e_1_2_10_19_1","doi-asserted-by":"crossref","DOI":"10.1139\/o01-210","volume":"80","author":"Schickel J.","year":"2002","journal-title":"Biochem. Cell Biol."},{"key":"e_1_2_10_20_1","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1329562","volume":"15","author":"Zhang T.","year":"2024","journal-title":"Front. Immunol."},{"key":"e_1_2_10_21_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41418-024-01347-w","volume":"31","author":"Polara R.","year":"2024","journal-title":"Cell Death Differ."},{"key":"e_1_2_10_22_1","doi-asserted-by":"crossref","DOI":"10.1046\/j.1460-9568.2000.00985.x","volume":"12","author":"Lee E. H.","year":"2000","journal-title":"Eur. J. Neurosci."},{"key":"e_1_2_10_23_1","volume":"25","author":"Kaur S.","year":"2021","journal-title":"Atlas Genet. Cytogenet. Oncol. Haematol."},{"key":"e_1_2_10_24_1","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.123.2.485","volume":"123","author":"Lindberg F. P.","year":"1993","journal-title":"J. Cell Biol."},{"key":"e_1_2_10_25_1","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.M106107200","volume":"276","author":"Rebres R. A.","year":"2001","journal-title":"J. Biol. Chem."},{"key":"e_1_2_10_26_1","doi-asserted-by":"crossref","DOI":"10.1042\/bj3040525","volume":"304","author":"Mawby W. J.","year":"1994","journal-title":"Biochem. J."},{"key":"e_1_2_10_27_1","volume":"13","author":"Cao Y.","year":"2026","journal-title":"Adv. Sci. (Weinheim)"},{"key":"e_1_2_10_28_1","doi-asserted-by":"crossref","DOI":"10.1002\/cac2.70040","volume":"45","author":"Zhang J.","year":"2025","journal-title":"Cancer Commun. (London)"},{"key":"e_1_2_10_29_1","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.M110.179663","volume":"286","author":"Kaur S.","year":"2011","journal-title":"J. Biol. Chem."},{"key":"e_1_2_10_30_1","volume":"26","author":"Kaur S.","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"e_1_2_10_31_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41591-019-0356-z","volume":"25","author":"Logtenberg M. E. W.","year":"2019","journal-title":"Nat. Med."},{"key":"e_1_2_10_32_1","doi-asserted-by":"crossref","DOI":"10.1038\/s42003-025-08938-4","volume":"8","author":"Plas\u2010van Duijn A.","year":"2025","journal-title":"Commun. Biol."},{"key":"e_1_2_10_33_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-025-59621-5","volume":"16","author":"Dai P.","year":"2025","journal-title":"Nat. Commun."},{"key":"e_1_2_10_34_1","doi-asserted-by":"crossref","DOI":"10.1210\/me.2007-0552","volume":"22","author":"Maile L. A.","year":"2008","journal-title":"Mol. Endocrinol."},{"key":"e_1_2_10_35_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.matbio.2014.05.007","volume":"37","author":"Kaur S.","year":"2014","journal-title":"Matrix Biol."},{"key":"e_1_2_10_36_1","doi-asserted-by":"crossref","DOI":"10.1158\/1541-7786.MCR-20-0956","volume":"19","author":"Shimizu A.","year":"2021","journal-title":"Mol. Cancer Res."},{"key":"e_1_2_10_37_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.109546","volume":"27","author":"Zimarino C.","year":"2024","journal-title":"iScience"},{"key":"e_1_2_10_38_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.immuni.2017.07.016","volume":"47","author":"Xu M. M.","year":"2017","journal-title":"Immunity"},{"key":"e_1_2_10_39_1","doi-asserted-by":"crossref","DOI":"10.1152\/ajpcell.00175.2021","volume":"321","author":"Roberts D. D.","year":"2021","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"e_1_2_10_40_1","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.M110.172304","volume":"285","author":"Kaur S.","year":"2010","journal-title":"J. Biol. Chem."},{"key":"e_1_2_10_41_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41590-025-02321-5","volume":"26","author":"Weng C. H.","year":"2025","journal-title":"Nat. Immunol."},{"key":"e_1_2_10_42_1","doi-asserted-by":"crossref","DOI":"10.1007\/s00262-023-03465-9","volume":"72","author":"Montero E.","year":"2023","journal-title":"Cancer Immunol., Immunother."},{"key":"e_1_2_10_43_1","doi-asserted-by":"crossref","DOI":"10.1136\/egastro-2025-100242","volume":"3","author":"Otuagomah J.","year":"2025","journal-title":"eGastroenterology"},{"key":"e_1_2_10_44_1","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.M407631200","volume":"279","author":"Brittain J. E.","year":"2004","journal-title":"J. Biol. Chem."},{"key":"e_1_2_10_45_1","doi-asserted-by":"crossref","DOI":"10.1111\/j.1538-7836.2005.01235.x","volume":"3","author":"Kato H.","year":"2005","journal-title":"J. Thromb. Haemostasis"},{"key":"e_1_2_10_46_1","volume":"13","author":"Yu P. C.","year":"2026","journal-title":"Adv. Sci. (Weinheim)"},{"key":"e_1_2_10_47_1","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.M301869200","volume":"278","author":"Lamy L.","year":"2003","journal-title":"J. Biol. Chem."},{"key":"e_1_2_10_48_1","doi-asserted-by":"crossref","DOI":"10.7150\/thno.40860","volume":"10","author":"Hu T.","year":"2020","journal-title":"Theranostics"},{"key":"e_1_2_10_49_1","doi-asserted-by":"crossref","DOI":"10.1093\/intimm\/dxab002","volume":"33","author":"Kitai Y.","year":"2021","journal-title":"Int. Immunol."},{"key":"e_1_2_10_50_1","doi-asserted-by":"crossref","DOI":"10.4161\/cc.10.1.14324","volume":"10","author":"Kaur S.","year":"2011","journal-title":"Cell Cycle"},{"key":"e_1_2_10_51_1","doi-asserted-by":"crossref","DOI":"10.4049\/jimmunol.1303116","volume":"193","author":"Kaur S.","year":"2014","journal-title":"J. Immunol."},{"key":"e_1_2_10_52_1","doi-asserted-by":"crossref","DOI":"10.1093\/cvr\/cvr356","volume":"93","author":"Bauer P. M.","year":"2012","journal-title":"Cardiovasc. Res."},{"key":"e_1_2_10_53_1","doi-asserted-by":"crossref","DOI":"10.7150\/ijbs.60782","volume":"17","author":"Jia X.","year":"2021","journal-title":"Int. J. Biol. Sci."},{"key":"e_1_2_10_54_1","doi-asserted-by":"crossref","DOI":"10.1182\/blood.2025029850","volume":"146","author":"R\u00f6llig C.","year":"2025","journal-title":"Blood"},{"key":"e_1_2_10_55_1","doi-asserted-by":"crossref","DOI":"10.3727\/096504018X15155538502359","volume":"27","author":"Liu X.","year":"2019","journal-title":"Oncol. Res."},{"key":"e_1_2_10_56_1","doi-asserted-by":"crossref","DOI":"10.1111\/nan.12795","volume":"48","author":"Zhang H.","year":"2022","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"e_1_2_10_57_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-022-29137-3","volume":"13","author":"Jiang N.","year":"2022","journal-title":"Nat. Commun."},{"key":"e_1_2_10_58_1","volume":"18","author":"Li Q.","year":"2025","journal-title":"Cancers (Basel)"},{"key":"e_1_2_10_59_1","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2025.1535382","volume":"16","author":"Jiang X.","year":"2025","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"e_1_2_10_60_1","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.abl9330","volume":"7","author":"Hsieh R. C.","year":"2022","journal-title":"Sci. Immunol."},{"key":"e_1_2_10_61_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2023.216205","volume":"564","author":"Lu J.","year":"2023","journal-title":"Cancer Lett."},{"key":"e_1_2_10_62_1","doi-asserted-by":"crossref","DOI":"10.1056\/NEJMoa1807315","volume":"379","author":"Advani R.","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"e_1_2_10_63_1","doi-asserted-by":"crossref","DOI":"10.1200\/JCO.18.02018","volume":"37","author":"Sikic B. I.","year":"2019","journal-title":"J. Clin. Oncol."},{"key":"e_1_2_10_64_1","volume":"10","author":"Qu T.","year":"2022","journal-title":"J. Immunother. Cancer"},{"key":"e_1_2_10_65_1","author":"Ahn J. S.","year":"2025","journal-title":"Cancer Res. Treat."},{"key":"e_1_2_10_66_1","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.884196","volume":"12","author":"Thaker Y. R.","year":"2022","journal-title":"Front. Oncol."},{"key":"e_1_2_10_67_1","doi-asserted-by":"crossref","DOI":"10.1158\/1535-7163.MCT-19-1079","volume":"19","author":"Puro R. J.","year":"2020","journal-title":"Mol. Cancer Ther."},{"key":"e_1_2_10_68_1","volume":"11","author":"Helden M. J.","year":"2023","journal-title":"J. Immunother. Cancer"},{"key":"e_1_2_10_69_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0304985","volume":"19","author":"Sue M.","year":"2024","journal-title":"PLoS One"},{"key":"e_1_2_10_70_1","doi-asserted-by":"crossref","DOI":"10.1200\/JCO.22.01794","volume":"41","author":"Sallman D. A.","year":"2023","journal-title":"J. Clin. Oncol."},{"key":"e_1_2_10_71_1","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2024.1378647","volume":"14","author":"Jiang C.","year":"2024","journal-title":"Front. Oncol."},{"key":"e_1_2_10_72_1","doi-asserted-by":"crossref","DOI":"10.1182\/blood.2024027408","volume":"146","author":"Zeidner J. F.","year":"2025","journal-title":"Blood"},{"key":"e_1_2_10_73_1","doi-asserted-by":"crossref","DOI":"10.1182\/blood.2024027506","volume":"146","author":"Daver N.","year":"2025","journal-title":"Blood"},{"key":"e_1_2_10_74_1","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2024-010565","volume":"13","author":"Lakhani N. J.","year":"2025","journal-title":"J. Immunother. Cancer"},{"key":"e_1_2_10_75_1","doi-asserted-by":"crossref","DOI":"10.1007\/s10238-025-01915-5","volume":"25","author":"Mirza W.","year":"2025","journal-title":"Clin. Exp. Med."},{"key":"e_1_2_10_76_1","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1348852","volume":"15","author":"Xu Y.","year":"2024","journal-title":"Front. Immunol."},{"key":"e_1_2_10_77_1","volume":"7","author":"Zhang H.","year":"2023","journal-title":"HemaSphere"},{"key":"e_1_2_10_78_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.trecan.2024.07.002","volume":"10","author":"Herrera M.","year":"2024","journal-title":"Trends Cancer"},{"key":"e_1_2_10_79_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2024.101068","volume":"74","author":"Zhang B.","year":"2024","journal-title":"Drug Resistance Updates"},{"key":"e_1_2_10_80_1","doi-asserted-by":"crossref","DOI":"10.1186\/s13045-025-01742-x","volume":"18","author":"Wang J. T.","year":"2025","journal-title":"J. Hematol. Oncol."},{"key":"e_1_2_10_81_1","doi-asserted-by":"crossref","DOI":"10.1200\/JCO.2025.43.4_suppl.332","volume":"43","author":"Shitara K.","year":"2025","journal-title":"J. Clin. Oncol."},{"key":"e_1_2_10_82_1","doi-asserted-by":"crossref","DOI":"10.1016\/S1470-2045(21)00584-2","volume":"22","author":"Lakhani N. J.","year":"2021","journal-title":"Lancet Oncol."},{"key":"e_1_2_10_83_1","volume":"110","author":"Kim T. M.","year":"2025","journal-title":"Haematologica"},{"key":"e_1_2_10_84_1","doi-asserted-by":"crossref","DOI":"10.1186\/s13046-022-02256-x","volume":"41","author":"Cendrowicz E.","year":"2022","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"e_1_2_10_85_1","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13246229","volume":"13","author":"Dizman N.","year":"2021","journal-title":"Cancers"},{"key":"e_1_2_10_86_1","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1027235","volume":"13","author":"Son J.","year":"2022","journal-title":"Front. Immunol."},{"key":"e_1_2_10_87_1","doi-asserted-by":"crossref","DOI":"10.1186\/s40364-023-00456-x","volume":"11","author":"Yang H.","year":"2023","journal-title":"Biomarker Res."},{"key":"e_1_2_10_88_1","doi-asserted-by":"crossref","DOI":"10.1038\/mt.2013.135","volume":"21","author":"Wang Y.","year":"2013","journal-title":"Mol. Ther."},{"key":"e_1_2_10_89_1","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202004240","volume":"16","author":"Zhang Y. R.","year":"2020","journal-title":"Small"},{"key":"e_1_2_10_90_1","doi-asserted-by":"crossref","DOI":"10.1007\/s40820-021-00647-x","volume":"13","author":"Huang L.","year":"2021","journal-title":"Nano\u2010Micro Lett."},{"key":"e_1_2_10_91_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.120964","volume":"275","author":"Cheng L.","year":"2021","journal-title":"Biomaterials"},{"key":"e_1_2_10_92_1","doi-asserted-by":"crossref","DOI":"10.7150\/thno.72310","volume":"12","author":"Li C.","year":"2022","journal-title":"Theranostics"},{"key":"e_1_2_10_93_1","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.897561","volume":"12","author":"Zhang B.","year":"2022","journal-title":"Front. Oncol."},{"key":"e_1_2_10_94_1","doi-asserted-by":"crossref","DOI":"10.1021\/acsnano.5c02746","volume":"19","author":"Luo J. Q.","year":"2025","journal-title":"ACS Nano"},{"key":"e_1_2_10_95_1","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1142374","volume":"14","author":"Li S.","year":"2023","journal-title":"Front. Pharmacol."},{"key":"e_1_2_10_96_1","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202303835","volume":"35","author":"Tang L.","year":"2023","journal-title":"Adv. Mater."},{"key":"e_1_2_10_97_1","doi-asserted-by":"crossref","DOI":"10.1007\/s12274-023-5397-4","volume":"16","author":"Wang M.","year":"2023","journal-title":"Nano Res."},{"key":"e_1_2_10_98_1","volume":"12","author":"Li Z.","year":"2024","journal-title":"J. Immunother. Cancer"},{"key":"e_1_2_10_99_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.mtbio.2025.101573","volume":"31","author":"Tan S.","year":"2025","journal-title":"Mater. Today Bio"},{"key":"e_1_2_10_100_1","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adi2046","volume":"10","author":"Saha T.","year":"2024","journal-title":"Sci. Adv."},{"key":"e_1_2_10_101_1","doi-asserted-by":"crossref","DOI":"10.1186\/s12964-024-01555-4","volume":"22","author":"Jin S.","year":"2024","journal-title":"Cell Commun. Signaling"},{"key":"e_1_2_10_102_1","doi-asserted-by":"crossref","DOI":"10.1021\/acsmedchemlett.2c00256","volume":"13","author":"Park E.","year":"2022","journal-title":"ACS Med. Chem. Lett."},{"key":"e_1_2_10_103_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41392-023-01715-x","volume":"8","author":"Yu L.","year":"2023","journal-title":"Signal Transduction Targeted Ther."},{"key":"e_1_2_10_104_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2025.118469","volume":"132","author":"Li R.","year":"2026","journal-title":"Bioorg. Med. Chem."},{"key":"e_1_2_10_105_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.tranon.2018.12.001","volume":"12","author":"Cabrales P.","year":"2019","journal-title":"Transl. Oncol."},{"key":"e_1_2_10_106_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.tranon.2021.101129","volume":"14","author":"Li Z.","year":"2021","journal-title":"Transl. Oncol."},{"key":"e_1_2_10_107_1","doi-asserted-by":"crossref","DOI":"10.1186\/s12967-023-04479-8","volume":"21","author":"Chen Y.","year":"2023","journal-title":"J. Transl. Med."},{"key":"e_1_2_10_108_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41423-024-01220-3","volume":"21","author":"Zhang H.","year":"2024","journal-title":"Cell. Mol. Immunol."},{"key":"e_1_2_10_109_1","doi-asserted-by":"crossref","DOI":"10.1038\/s42003-025-09331-x","volume":"9","author":"Chen Y.","year":"2025","journal-title":"Commun. Biol."},{"key":"e_1_2_10_110_1","volume":"13","author":"Du F.","year":"2025","journal-title":"J. Immunother. Cancer"},{"key":"e_1_2_10_111_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-025-59326-9","volume":"16","author":"Chen S.","year":"2025","journal-title":"Nat. Commun."},{"key":"e_1_2_10_112_1","volume":"10","author":"Chen H.","year":"2022","journal-title":"J. Immunother. Cancer"},{"key":"e_1_2_10_113_1","doi-asserted-by":"crossref","DOI":"10.1182\/blood.2022016101","volume":"141","author":"Dacek M. M.","year":"2023","journal-title":"Blood"},{"key":"e_1_2_10_114_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41586-024-07443-8","volume":"630","author":"Yamada\u2010Hunter S. A.","year":"2024","journal-title":"Nature"},{"key":"e_1_2_10_115_1","doi-asserted-by":"crossref","DOI":"10.1172\/JCI161660","volume":"134","author":"Stefanidis E.","year":"2024","journal-title":"J. Clin. Invest."},{"key":"e_1_2_10_116_1","doi-asserted-by":"crossref","DOI":"10.1111\/febs.70192","volume":"292","author":"Muneekaew S.","year":"2025","journal-title":"FEBS J."},{"key":"e_1_2_10_117_1","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2022-005857","volume":"11","author":"Beckett A. N.","year":"2023","journal-title":"J. Immunother. Cancer"},{"key":"e_1_2_10_118_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2019.110546","volume":"184","author":"Guo Z.","year":"2019","journal-title":"Colloids Surf., B"},{"key":"e_1_2_10_119_1","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202102712","volume":"11","author":"Lu Y.","year":"2022","journal-title":"Adv. Healthcare Mater."},{"key":"e_1_2_10_120_1","doi-asserted-by":"crossref","DOI":"10.32604\/or.2023.030767","volume":"32","author":"Xiao J.","year":"2024","journal-title":"Oncol. Res."},{"key":"e_1_2_10_121_1","doi-asserted-by":"crossref","DOI":"10.1007\/s00262-025-04281-z","volume":"75","author":"Tang Q.","year":"2026","journal-title":"Cancer Immunol., Immunother."},{"key":"e_1_2_10_122_1","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202403108","volume":"14","author":"Li S.","year":"2025","journal-title":"Adv. Healthcare Mater."},{"key":"e_1_2_10_123_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2023.01.038","volume":"355","author":"Gong M.","year":"2023","journal-title":"J. Controlled Release"},{"key":"e_1_2_10_124_1","doi-asserted-by":"crossref","DOI":"10.1186\/s12951-025-03485-w","volume":"23","author":"Liao H.","year":"2025","journal-title":"J. Nanobiotechnol."},{"key":"e_1_2_10_125_1","doi-asserted-by":"crossref","DOI":"10.1186\/s12951-024-02883-w","volume":"22","author":"Li M.","year":"2024","journal-title":"J. Nanobiotechnol."},{"key":"e_1_2_10_126_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2021.01.023","volume":"331","author":"Sheybani N. D.","year":"2021","journal-title":"J. Controlled Release"},{"key":"e_1_2_10_127_1","doi-asserted-by":"crossref","DOI":"10.1021\/acs.nanolett.4c00003","volume":"24","author":"Wang S.","year":"2024","journal-title":"Nano Lett."},{"key":"e_1_2_10_128_1","volume":"13","author":"Yu L. B.","year":"2026","journal-title":"Adv. Sci. (Weinheim)"},{"key":"e_1_2_10_129_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-025-57133-w","volume":"16","author":"Kim S.","year":"2025","journal-title":"Nat. Commun."},{"key":"e_1_2_10_130_1","volume":"8","author":"Wang H.","year":"2020","journal-title":"J. Immunother. Cancer"},{"key":"e_1_2_10_131_1","doi-asserted-by":"crossref","DOI":"10.1038\/s43018-025-00919-0","volume":"6","author":"Schrank B. R.","year":"2025","journal-title":"Nat. Cancer"},{"key":"e_1_2_10_132_1","doi-asserted-by":"crossref","DOI":"10.1021\/acsnano.5c12781","volume":"19","author":"Yang C.","year":"2025","journal-title":"ACS Nano"},{"key":"e_1_2_10_133_1","doi-asserted-by":"crossref","DOI":"10.1007\/s10555-025-10269-z","volume":"44","author":"Ooki A.","year":"2025","journal-title":"Cancer Metastasis Rev."},{"key":"e_1_2_10_134_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.113740","volume":"144","author":"Yang Y.","year":"2025","journal-title":"Int. Immunopharmacol."},{"key":"e_1_2_10_135_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.xcrm.2025.102092","volume":"6","author":"Gao C.","year":"2025","journal-title":"Cell Rep. Med."},{"key":"e_1_2_10_136_1","volume":"110","author":"Li M.","year":"2025","journal-title":"Haematologica"},{"key":"e_1_2_10_137_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41586-019-1456-0","volume":"572","author":"Barkal A. A.","year":"2019","journal-title":"Nature"},{"key":"e_1_2_10_138_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41590-017-0004-z","volume":"19","author":"Barkal A. A.","year":"2018","journal-title":"Nat. Immunol."},{"key":"e_1_2_10_139_1","doi-asserted-by":"crossref","DOI":"10.1007\/s11523-025-01130-y","volume":"20","author":"Eng C.","year":"2025","journal-title":"Targeted Oncol."},{"key":"e_1_2_10_140_1","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.757480","volume":"13","author":"Zhao H.","year":"2022","journal-title":"Front. Immunol."}],"container-title":["Smart Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smo2.70079","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/smo2.70079","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smo2.70079","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T06:00:04Z","timestamp":1784181604000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/smo2.70079"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,15]]},"references-count":139,"alternative-id":["10.1002\/smo2.70079"],"URL":"https:\/\/doi.org\/10.1002\/smo2.70079","archive":["Portico"],"relation":{},"ISSN":["2751-4587","2751-4595"],"issn-type":[{"value":"2751-4587","type":"print"},{"value":"2751-4595","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,15]]},"assertion":[{"value":"2026-03-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70079"}}