{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T07:24:38Z","timestamp":1787124278314,"version":"build-2736575974"},"reference-count":56,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Smart Molecules"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Senescence\u2010associated \u03b2\u2010galactosidase (SA\u2010\u03b2\u2010gal) is a key biomarker of cellular senescence and has been demonstrated to be a major driver of various age\u2010related diseases and tumor resistance. However, noninvasive in vivo imaging of SA\u2010\u03b2\u2010gal remains challenging due to the poor membrane permeability of existing probes, their reliance on intratumoral injection, and limited blood\u2010brain barrier (BBB) permeability. This study reports a novel, rationally designed near\u2010infrared (NIR) fluorescent probe,\n                    <jats:bold>DCIP\u2010AcGal<\/jats:bold>\n                    , which involves a synergistic lipophilicity\u2010oriented design strategy by leveraging a BBB\u2010penetrating fluorophore with acetylated \u03b2\u2010galactose. Its SA\u2010\u03b2\u2010gal\u2010sensitive NIR emission property enables deep\u2010tissue imaging of senescent cells with low background and high signal\u2010to\u2010noise ratio. The probe's favorable lipophilicity facilitates passive diffusion through the cell membranes, ensuring efficient activation by SA\u2010\u03b2\u2010gal within the lysosomes. Its specificity for imaging senescent cells has been validated through GLB1 knockdown, and its fluorescence intensity and distribution correlate positively with p21 expression. Following intravenous injection,\n                    <jats:bold>DCIP\u2010AcGal<\/jats:bold>\n                    enables noninvasive imaging of palbociclib\u2010induced tumor senescence in living mice. Furthermore, due to its favorable lipophilicity, the probe crosses the BBB, allowing for the assessment of senescence accumulation in the brains of aged mice. These findings demonstrate that probe\n                    <jats:bold>DCIP\u2010AcGal<\/jats:bold>\n                    provides a valuable tool for investigating senescence biology and monitoring the efficacy of senotherapeutic interventions.\n                  <\/jats:p>","DOI":"10.1002\/smo2.70091","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T06:39:27Z","timestamp":1787121567000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Rational design of a lipophilic \u03b2\u2010galactosidase\u2010responsive near\u2010infrared probe for in vivo imaging of cellular senescence"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-5581-325X","authenticated-orcid":false,"given":"Jiani","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine Zhejiang Cancer Hospital Hangzhou Institute of Medicine Chinese Academy of Sciences  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