{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T15:03:43Z","timestamp":1789571023458,"version":"build-2803163510"},"reference-count":83,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Smart Molecules"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Glioma poses a formidable therapeutic challenge due to its cellular heterogeneity, invasiveness and the protective blood\u2010brain barrier (BBB). Boron neutron capture therapy represents a promising binary targeted radiotherapy, but its efficacy is hampered by insufficient tumor\u2010specific accumulation, limited real\u2010time monitoring capabilities of boron agents, and the immunosuppressive tumor microenvironment (TME). Although L\u20104\u2010boronophenylalanine (BPA) is the only boron agent approved in Japan for Boron neutron capture therapy, its suboptimal tumor specificity and rapid metabolism limit effective accumulation in glioma. In this work, we engineered a theranostic strategy based on a brain\u2010targeting nanoplatform (DM&amp;Ce6@COF\u2010Ang). Boron\u2010embedded APTES\u2010COF\u20101, with a high intrinsic boron content of 13.5%, served as both a therapeutic boron agent and a nanocarrier to deliver the STING agonist DMXAA (abbreviated as DM) and the fluorescent probe chlorin\n                    <jats:italic>e<\/jats:italic>\n                    6 (Ce6). The targeting ligand Angiopep\u20102 was utilized to facilitate low\u2010density lipoprotein\u2010related protein\u20101 (lipoprotein receptor\u2010related protein 1) receptor\u2010mediated transcytosis across the BBB. Specifically, DM@COF\u2010Ang demonstrated superior tumor\u2010specific accumulation in orthotopic glioma\u2010bearing mice, reaching a tumor boron concentration of 11.3\u00a0\u00b1\u00a02.9\u00a0ppm (natural abundance boron, \u223c19.8%\n                    <jats:sup>10<\/jats:sup>\n                    B) (T\/N\u00a0\u2248\u00a04.0), whereas BPA yielded only 1.9\u20133.8\u00a0ppm (T\/N\u00a0\u2248\u00a02.0). Simultaneously, the nanoplatform selectively delivered DMXAA to glioma, triggering STING pathway activation and reprogramming the immunosuppressive TME. Importantly, the co\u2010delivered Ce6 functioned as a modal imaging agent, enabling accurate tracking of DM@COF\u2010Ang biodistribution and confirming the feasibility of real\u2010time monitoring. This multifunctional nanoplatform achieved synergistic tumor\u2010specific boron delivery, real\u2010time pharmacokinetic monitoring, and immunomodulation. The modular design establishes a versatile foundation for developing personalized, potential BNCT\u2010based combination therapies.\n                  <\/jats:p>","DOI":"10.1002\/smo2.70107","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T14:22:04Z","timestamp":1789568524000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Boron\u2010embedded multifunctional nanoplatform toward potential combined boron neutron capture therapy and immunomodulation in glioma"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-1516-0726","authenticated-orcid":false,"given":"Yiming","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Engineering State Key Laboratory of Fine Chemicals School of Chemical Engineering Dalian University of Technology  Dalian China"},{"name":"State Key Laboratory of Fine Chemicals Frontiers Science Center for Smart Materials Oriented Chemical Engineering School of Chemical Engineering Dalian University of Technology  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Urology First Affiliated Hospital of Dalian Medical University  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bangjian","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Fine Chemicals Frontiers Science Center for Smart Materials Oriented Chemical Engineering School of Chemical Engineering Dalian University of Technology  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6876-4697","authenticated-orcid":false,"given":"Kun","family":"Shao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Fine Chemicals Frontiers Science Center for Smart Materials Oriented Chemical Engineering School of Chemical Engineering Dalian University of Technology  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianlong","family":"Su","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Fine Chemicals Frontiers Science Center for Smart Materials Oriented Chemical Engineering School of Chemical Engineering Dalian University of Technology  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Fine Chemicals Frontiers Science Center for Smart Materials Oriented Chemical Engineering School of Chemical Engineering Dalian University of Technology  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Engineering State Key Laboratory of Fine Chemicals School of Chemical Engineering Dalian University of Technology  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihao","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Fine Chemicals Frontiers Science Center for Smart Materials Oriented Chemical Engineering School of Chemical Engineering Dalian University of Technology  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JinRong","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Fine Chemicals Frontiers Science Center for Smart Materials Oriented Chemical Engineering School of Chemical Engineering Dalian University of Technology  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9172-1388","authenticated-orcid":false,"given":"Guanyi","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Fine Chemicals Frontiers Science Center for Smart Materials Oriented Chemical Engineering School of Chemical Engineering Dalian University of Technology  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Fine Chemicals Frontiers Science Center for Smart Materials Oriented Chemical Engineering School of Chemical Engineering Dalian University of Technology  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Fine Chemicals Frontiers Science Center for Smart Materials Oriented Chemical Engineering School of Chemical Engineering Dalian University of Technology  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanhao","family":"Liu","sequence":"additional","affiliation":[{"name":"Neuboron Medtech Ltd.  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