{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T17:29:25Z","timestamp":1764350965984,"version":"3.41.2"},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,5,26]],"date-time":"2024-05-26T00:00:00Z","timestamp":1716681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Small Science"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:p>Progesterone is an endogenous steroid hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. Progesterone crystallization techniques have previously reported. Among these techniques, solvent crystallization and different solvent:anti\u2010solvent systems are considered. Herein, the selective development of either hollow\u2010like or condensed progesterone microcrystals in elevated yield with controlled polymorphism, habit, and release is described for the first time. For the hollow microcrystals, isopropyl alcohol (IPA) and double\u2010deionized water (DDW) system is developed as solvent:anti\u2010solvent, while acetonitrile (AcN) and DDW system are developed for the condensed microcrystals. The microcrystals obtained from both developed crystallization systems are thoroughly investigated with varied microscopic techniques, including brightfield and scanning electron microscopy (SEM), thermal analysis by differential scanning calorimetry (DSC), and crystallography by powder X\u2010ray diffraction (PXRD) and single XRD, and have been compared. Results show that the crystals of the IPA:DDW crystallization system are hollow and exhibit several habits, whereas the microcrystals of the AcN:DDW crystallization system are more condensed. However, both systems are found to have a wide crystal size distribution of one stable polymorph and are thus highly useful for tunable release. More importantly, these microcrystals exhibit elongated and slow release for 14\u2009days under an expedited release conditions model, indicating suitability for long\u2010term and potential localized release applications.<\/jats:p>","DOI":"10.1002\/smsc.202400045","type":"journal-article","created":{"date-parts":[[2024,5,26]],"date-time":"2024-05-26T10:24:31Z","timestamp":1716719071000},"source":"Crossref","is-referenced-by-count":1,"title":["Engineering Long\u2010Releasing Hollow\u2010like or Condensed Progesterone Hormone Microcrystals with Controlled Polymorphism"],"prefix":"10.1002","volume":"4","author":[{"given":"Merna","family":"Shaheen\u2010Mualim","sequence":"first","affiliation":[{"name":"The Laboratory for Advanced Functional\/Medicinal Polymers &amp; Smart Drug Delivery, Technologies, The Wolfson Faculty of Chemical Engineering Technion\u2010Israel Institute of Technology  Haifa 3200003 Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edwar","family":"Odeh","sequence":"additional","affiliation":[{"name":"The Laboratory for Advanced Functional\/Medicinal Polymers &amp; Smart Drug Delivery, Technologies, The Wolfson Faculty of Chemical Engineering Technion\u2010Israel Institute of Technology  Haifa 3200003 Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neta","family":"Kutner","sequence":"additional","affiliation":[{"name":"The Laboratory for Advanced Functional\/Medicinal Polymers &amp; Smart Drug Delivery, Technologies, The Wolfson Faculty of Chemical Engineering Technion\u2010Israel Institute of Technology  Haifa 3200003 Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Hijazi","sequence":"additional","affiliation":[{"name":"The Laboratory for Advanced Functional\/Medicinal Polymers &amp; Smart Drug Delivery, Technologies, The Wolfson Faculty of Chemical Engineering Technion\u2010Israel Institute of Technology  Haifa 3200003 Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9801-5301","authenticated-orcid":false,"given":"Shady","family":"Farah","sequence":"additional","affiliation":[{"name":"The Laboratory for Advanced Functional\/Medicinal Polymers &amp; Smart Drug Delivery, Technologies, The Wolfson Faculty of Chemical Engineering Technion\u2010Israel Institute of Technology  Haifa 3200003 Israel"},{"name":"The Russell Berrie Nanotechnology Institute Technion\u2010Israel Institute of Technology  Haifa 3200003 Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,5,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2020.100856"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222011039"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1530\/JME-20-0091"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41563-019-0377-5"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202010929"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2017.12.030"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2013.01.053"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/cg5006727"},{"key":"e_1_2_8_10_1","first-page":"1493","volume":"11","author":"Tripathi R.","year":"2010","journal-title":"J. Am. Assoc. Pharm. Sci."},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-6031(02)00492-6"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.20983"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0026-265X(65)90093-7"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.21896"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/cg034206y"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600680214"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389557514666141013142436"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.3109\/10837450.2013.829096"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.1965.tb07679.x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.20983"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/sca.21045"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2004.02.030"},{"key":"e_1_2_8_23_1","unstructured":"Database of Progesterone JCPDS cards: 00\u2010029\u20101874 00\u2010010\u20100556 00\u2010037\u20101690."},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1107\/S0021889808042726"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1107\/S2053273314022207"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1107\/S2053273314026370"},{"key":"e_1_2_8_27_1","unstructured":"Mercury Software from CCDC https:\/\/www.ccdc.cam.ac.uk\/solutions\/software\/mercury\/."}],"container-title":["Small Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smsc.202400045","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T09:59:24Z","timestamp":1723111164000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/smsc.202400045"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,26]]},"references-count":26,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1002\/smsc.202400045"],"URL":"https:\/\/doi.org\/10.1002\/smsc.202400045","archive":["Portico"],"relation":{},"ISSN":["2688-4046","2688-4046"],"issn-type":[{"type":"print","value":"2688-4046"},{"type":"electronic","value":"2688-4046"}],"subject":[],"published":{"date-parts":[[2024,5,26]]},"article-number":"2400045"}}