{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:37:14Z","timestamp":1787776634250,"version":"build-2784847793"},"reference-count":128,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T00:00:00Z","timestamp":1716854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013169","name":"Ministero dell'Economia e delle Finanze","doi-asserted-by":"publisher","award":["PNC0000003"],"award-info":[{"award-number":["PNC0000003"]}],"id":[{"id":"10.13039\/501100013169","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["H29J21000140006"],"award-info":[{"award-number":["H29J21000140006"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Small Science"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:p>The authors, actively engaged in the development of mesoporous silica\u2010based solutions, initially for modified drug release, later for the smart administration of conventional chemotherapeutic cytotoxic drugs, present the evolution of the concept of targeted therapy across different disciplines. They also discuss the diverse therapeutic needs and related challenges (adverse drug effects) that have unfolded over the last 30\u2009years. Nanomedicine potentialities, mainly against cancers, that have emerged globally during the intense research activity of the last few decades, are critically discussed. The authors glimpse the growing potential of immune\u2010based therapeutic solutions, including those assisted by nanotechnology, as well as molecular targeted therapies (MTT) on which they focus. The advantages offered by targeted molecular therapies, despite the limits of monotargeted therapies, suggest the engineering of multi\u2010targeted therapies. Nanomedicine solutions such as ligand\u2010specific internalization and pH\u2010sensitive drug release that they have extensively tested and recently presented in open literature, still remain available instruments. According to the authors, MTT can offer shining perspectives in the near future that will depend on a thorough comprehension of nanostructures synthesis and tumor physiology. This article gives an interdisciplinary point of view tailored for non\u2010specialist readers imagining possible future scenarios in the field.<\/jats:p>","DOI":"10.1002\/smsc.202400113","type":"journal-article","created":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T03:18:33Z","timestamp":1716866313000},"source":"Crossref","is-referenced-by-count":34,"title":["The Advent of Molecular Targeted Therapies Against Cancer. Toward Multi\u2010Targeting Drugs Through Materials Engineering: A Possible Future Scenario"],"prefix":"10.1002","volume":"4","author":[{"given":"Marianna","family":"Puzzo","sequence":"first","affiliation":[{"name":"Services Department Laboratory of Clinical, Biomolecular and Genetic Analysis Hospital Facility Annunziata  87100 Cosenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marzia","family":"De Santo","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Health and Nutritional Sciences University of Calabria  via P. Bucci 87036 Arcavacata di Rende (CS) Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catia","family":"Morelli","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Health and Nutritional Sciences University of Calabria  via P. Bucci 87036 Arcavacata di Rende (CS) Italy"},{"name":"NanoSiliCal Devices srl  Via P. Bucci 44A 87036 Arcavacata di Rende (CS) Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Leggio","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Health and Nutritional Sciences University of Calabria  via P. Bucci 87036 Arcavacata di Rende (CS) Italy"},{"name":"NanoSiliCal Devices srl  Via P. Bucci 44A 87036 Arcavacata di Rende (CS) Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1983-8391","authenticated-orcid":false,"given":"Luigi","family":"Pasqua","sequence":"additional","affiliation":[{"name":"NanoSiliCal Devices srl  Via P. Bucci 44A 87036 Arcavacata di Rende (CS) Italy"},{"name":"Department of Environmental Engineering University of Calabria  via P. Bucci 87036 Arcavacata di Rende (CS) Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.13476"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.01.016"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/179663a0"},{"key":"e_1_2_10_5_1","first-page":"259","volume":"44","author":"Jones R.","year":"2016","journal-title":"Medicine"},{"key":"e_1_2_10_6_1","first-page":"119","volume":"14","author":"Rutaman R. J.","year":"1954","journal-title":"Cancer Res."},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1074"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568011023354146"},{"key":"e_1_2_10_9_1","first-page":"1531","volume":"34","author":"Papanastasopoulos P.","year":"2014","journal-title":"Anticancer Res."},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm10030113"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21103483"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.8b00607"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-409X(02)00042-X"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms16011772"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micromeso.2007.01.045"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1049\/iet-nbt.2016.0120"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/cm051014c"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja0645943"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1039\/c1nr10253b"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2022.122099"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.05-4288fje"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1166\/jnn.2010.1917"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.200902355"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.10.167"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2022.100472"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2QM01009G"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2022.103903"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.3c07541"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0NR08887K"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2021.11.044"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8QM00438B"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9NA00249A"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep05080"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2022.214687"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.12403"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-022-01605-4"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S596"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2012.03.020"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2022.02.025"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-022-01310-1"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-022-01265-3"},{"key":"e_1_2_10_42_1","unstructured":"U.S. Department of Health and Human Services Food and Drug Administration Guidance for Industry on Drug Products Including Biological Products that Contain Nanomaterials https:\/\/www.fda.gov\/files\/drugs\/published\/Drug\u2010Products\u2010\u2010Including\u2010Biological\u2010Products\u2010\u2010that\u2010Contain\u2010Nanomaterials\u2010\u2010\u2010Guidance\u2010for\u2010Industry.pdf(accessed: January 2024)."},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2020.05.008"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408440903120975"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.flm.2017.06.001"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-genom-083115-022413"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-018-0782-4"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)00114-8"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2004.08.024"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddv254"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI154943"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2015.10.021"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2559"},{"key":"e_1_2_10_54_1","first-page":"14","volume":"12","author":"Scott A. M.","year":"2012","journal-title":"Cancer Immunother."},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2744"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.9b01456"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2017.05.016"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2020.114224"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2020.112831"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00572-w"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110009"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1858"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aab1433"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.8b00506"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2018.09.005"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-19-1236"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-020-00652-y"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2023.03.003"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30030-4"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-061516-121357"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20051115"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202110305"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.00662"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-019-0028-1"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(22)00621-0"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-37029-3"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.118"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-017-0566-9"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2021.106055"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2006.12.006"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.8b00760"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2016.07.055"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.117"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2212851"},{"key":"e_1_2_10_85_1","volume-title":"Drug Selectivity","author":"Merk D.","year":"2017"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568026618666180118153502"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01642-x"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202005709"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12274-022-4967-1"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cllc.2022.11.004"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1080\/14737140.2022.2016397"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-20-0071"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-021-01533-x"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.2c00213"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.21037\/tlcr.2019.06.01"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.21037\/tlcr-23-160"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-37201-6"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.1186\/s11658-022-00332-w"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano13172476"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djm135"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568026618666180118155847"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3cc45220d"},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mattod.2015.11.025"},{"key":"e_1_2_10_104_1","doi-asserted-by":"publisher","DOI":"10.1002\/marc.201800917"},{"key":"e_1_2_10_105_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201002639"},{"key":"e_1_2_10_106_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano11092222"},{"key":"e_1_2_10_107_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.5b00456"},{"key":"e_1_2_10_108_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.0c08404"},{"key":"e_1_2_10_109_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3NR00642E"},{"key":"e_1_2_10_110_1","doi-asserted-by":"publisher","DOI":"10.1002\/cssc.200800183"},{"key":"e_1_2_10_111_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10934-012-9663-1"},{"key":"e_1_2_10_112_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201705691"},{"key":"e_1_2_10_113_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202200756"},{"key":"e_1_2_10_114_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2306441"},{"key":"e_1_2_10_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2023.10.117"},{"key":"e_1_2_10_116_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2212419"},{"key":"e_1_2_10_117_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2308795"},{"key":"e_1_2_10_118_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2026982"},{"key":"e_1_2_10_119_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-019-0567-y"},{"key":"e_1_2_10_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trecan.2020.01.011"},{"key":"e_1_2_10_121_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201901989"},{"key":"e_1_2_10_122_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-021-02910-6"},{"key":"e_1_2_10_123_1","doi-asserted-by":"publisher","DOI":"10.2217\/fon-2021-0688"},{"key":"e_1_2_10_124_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40580-021-00282-7"},{"key":"e_1_2_10_125_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-020-0090-8"},{"key":"e_1_2_10_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2019.12.021"},{"key":"e_1_2_10_127_1","doi-asserted-by":"publisher","DOI":"10.1021\/accountsmr.2c00072"},{"key":"e_1_2_10_128_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm12050673"},{"key":"e_1_2_10_129_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.13698"}],"container-title":["Small Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smsc.202400113","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T06:00:28Z","timestamp":1723096828000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/smsc.202400113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,28]]},"references-count":128,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1002\/smsc.202400113"],"URL":"https:\/\/doi.org\/10.1002\/smsc.202400113","archive":["Portico"],"relation":{},"ISSN":["2688-4046","2688-4046"],"issn-type":[{"value":"2688-4046","type":"print"},{"value":"2688-4046","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,28]]},"article-number":"2400113"}}