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There is a recent resurgence of interest in intravenous administration of BCG. However, direct injection of live BCG bacteria into the bloodstream of human beings is not likely to be practical due to safety concerns. In this study, it is showed that debris of BCG\u2010infected macrophages induces activation and maturation of dendritic cells (DCs) in\u2009vitro, and an intravenous DCs vaccine phagocytosing noninfective cell debris induces robust antigen\u2010specific T\u2010cell immune responses and immune protection against <jats:italic>Mycobacterium tuberculosis<\/jats:italic> infection in murine models. Further, an investigator\u2010initiated clinical trial shows the safety of a DCs vaccine harboring the noninfective <jats:italic>Mycobacterium vaccae<\/jats:italic> vaccine. Infusions of naive DCs and DCs harboring <jats:italic>Mycobacterium vaccae<\/jats:italic> are well tolerated and safe in six active TB patients. 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