{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:04:39Z","timestamp":1792677879791,"version":"4.5.0"},"reference-count":191,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T00:00:00Z","timestamp":1734912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82202344"],"award-info":[{"award-number":["82202344"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["92249303"],"award-info":[{"award-number":["92249303"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20241808"],"award-info":[{"award-number":["BK20241808"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2024J01221"],"award-info":[{"award-number":["2024J01221"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Small Science"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:p>Osteoporosis (OP) is a systemic and retrogressive disease characterized by decreased bone density and fragile bone microstructure. Extracellular vesicles (EVs), a cell\u2010free system with a phospholipid bilayer released by cells that cannot be replicated, have unique nanostructure, stable drug\u2010loading capacity, and good biocompatibility, playing an important role in regulating the gut\u2010skeletal axis. A growing body of research demonstrates that gut microbiota (GM) influence the development of OS, while bacteria\u2010derived EVs (BEVs) have become a new dialogue medium between the gut and bone. Additionally, organoids are 3D cell clusters in\u2009vitro that highly simulate the structure and function of corresponding organs. Intestinal organoids\u2010derived EVs (IOEVs) serve as another promising communication medium between the gut and bone due to their significant physiological effects. Herein, three types of gut\u2010bone axes, including the traditional, BEVs\u2010based, and IOEVs\u2010based gut\u2010bone axes are innovatively proposed. The impact of the BEVs\u2010based and IOEVs\u2010based gut\u2010bone axes on OP is focused. The comprehensive summary of three types of gut\u2010bone axes will reveal the relationship between intestinal and bone and provide new solution to OP therapy.<\/jats:p>","DOI":"10.1002\/smsc.202400474","type":"journal-article","created":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T05:49:18Z","timestamp":1734932958000},"source":"Crossref","is-referenced-by-count":28,"title":["Extracellular Vesicles in Gut\u2010Bone Axis: Novel Insights and Therapeutic Opportunities for Osteoporosis"],"prefix":"10.1002","volume":"5","author":[{"given":"Han","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Orthopedics, Xinhua Hospital Shanghai Jiao Tong University School of Medicine  Shanghai 200092 China"},{"name":"Institute of Translational Medicine Shanghai University  Shanghai 200444 China"},{"name":"Organoid Research Center Shanghai University  Shanghai 200444 China"},{"name":"National Center for Translational Medicine (Shanghai) SHU Branch Shanghai University  Shanghai 200444 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiyang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Xinhua Hospital Shanghai Jiao Tong University School of Medicine  Shanghai 200092 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijian","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Shanghai Zhongye Hospital  Shanghai 200941 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1966-6767","authenticated-orcid":false,"given":"Bo","family":"Situ","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Nanfang Hospital Southern Medical University  Guangzhou 510515 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4285-7144","authenticated-orcid":false,"given":"Guangchao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Xinhua Hospital Shanghai Jiao Tong University School of Medicine  Shanghai 200092 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3407-4532","authenticated-orcid":false,"given":"Ke","family":"Xu","sequence":"additional","affiliation":[{"name":"Institute of Translational Medicine Shanghai University  Shanghai 200444 China"},{"name":"Organoid Research Center Shanghai University  Shanghai 200444 China"},{"name":"National Center for Translational Medicine (Shanghai) SHU Branch Shanghai University  Shanghai 200444 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7080-263X","authenticated-orcid":false,"given":"Jiacan","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Xinhua Hospital Shanghai Jiao Tong University School of Medicine  Shanghai 200092 China"},{"name":"Institute of Translational Medicine Shanghai University  Shanghai 200444 China"},{"name":"Organoid Research Center Shanghai University  Shanghai 200444 China"},{"name":"National Center for Translational Medicine (Shanghai) SHU Branch Shanghai University  Shanghai 200444 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,23]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2193-0"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/550S15a"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.21106"},{"key":"e_1_2_11_4_2","first-page":"248","volume":"4","author":"Song P.","year":"2023","journal-title":"Biomater. Transl."},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compositesb.2023.110610"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b00241"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abl6432"},{"key":"e_1_2_11_6_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2023.122066"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2023.2190304"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022017514"},{"key":"e_1_2_11_7_3","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2022.2047005"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12159"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41413-023-00264-x"},{"key":"e_1_2_11_8_3","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202005709"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12404"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202403199"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aau6977"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202300552"},{"key":"e_1_2_11_12_1","author":"Cheng L.","year":"2022","journal-title":"Nat. Rev. Drug Discov."},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-022-00763-8"},{"key":"e_1_2_11_12_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2023.01.002"},{"key":"e_1_2_11_12_4","author":"Han R.","year":"2023","journal-title":"Nano Res."},{"key":"e_1_2_11_12_5","doi-asserted-by":"publisher","DOI":"10.1080\/20013078.2018.1535750"},{"key":"e_1_2_11_12_6","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12404"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.02.014"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abg8335"},{"key":"e_1_2_11_13_3","doi-asserted-by":"publisher","DOI":"10.1002\/INMD.20220003"},{"key":"e_1_2_11_13_4","doi-asserted-by":"publisher","DOI":"10.1002\/INMD.20230019"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.78034"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.12.006"},{"key":"e_1_2_11_14_3","doi-asserted-by":"publisher","DOI":"10.20517\/evcna.2022.04"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-022-00723-9"},{"key":"e_1_2_11_15_2","author":"Chen S.","year":"2022","journal-title":"Bioact. Mater."},{"key":"e_1_2_11_15_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2022.12.013"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05279-8"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaw9021"},{"key":"e_1_2_11_16_3","first-page":"270","volume":"4","author":"Deng S.","year":"2023","journal-title":"Biomater. Transl."},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07935"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/stmcls\/sxab020"},{"key":"e_1_2_11_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2021.04.002"},{"key":"e_1_2_11_18_3","author":"Park S. E.","year":"2022","journal-title":"Nat. Methods"},{"key":"e_1_2_11_18_4","doi-asserted-by":"publisher","DOI":"10.1002\/INMD.20230011"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-022-01643-8"},{"key":"e_1_2_11_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20351-5"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/bit.27606"},{"key":"e_1_2_11_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-023-04050-5"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2023.142842"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)02646-5"},{"key":"e_1_2_11_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202101107"},{"key":"e_1_2_11_22_3","first-page":"6","author":"Li X.","year":"2020","journal-title":"Sci. Adv."},{"key":"e_1_2_11_22_4","first-page":"280","volume":"4","author":"Tao Z.","year":"2023","journal-title":"Biomater. Transl."},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202004831"},{"key":"e_1_2_11_23_2","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2020.1867054"},{"key":"e_1_2_11_23_3","first-page":"22","author":"Seely K. D.","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"e_1_2_11_23_4","first-page":"131","author":"Lorenzo J.","year":"2021","journal-title":"J. Clin. Invest."},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i7.2219"},{"key":"e_1_2_11_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2016.08.003"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2014.11.004"},{"key":"e_1_2_11_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/SMMD.20230019"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI78366"},{"key":"e_1_2_11_26_2","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2023.2295432"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-022-03799-5"},{"key":"e_1_2_11_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2019.100946"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2845"},{"key":"e_1_2_11_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.05.041"},{"key":"e_1_2_11_28_3","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-019-0157-3"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02490-4"},{"key":"e_1_2_11_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.10.013"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1607235113"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2013.02.024"},{"key":"e_1_2_11_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2014.03.005"},{"key":"e_1_2_11_31_3","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2013.5312"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3838"},{"key":"e_1_2_11_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3921"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10068-019-00561-4"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.34133\/research.0089"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2062"},{"key":"e_1_2_11_35_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00036.2016"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2014-306947"},{"key":"e_1_2_11_36_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI86062"},{"key":"e_1_2_11_36_3","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1013492108"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.17399"},{"key":"e_1_2_11_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.02.034"},{"key":"e_1_2_11_37_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.112975"},{"key":"e_1_2_11_37_4","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2018.02.013"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2015.01.006"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/nqab194"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a031237"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI133473"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/INMD.20230017"},{"key":"e_1_2_11_42_2","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12406"},{"key":"e_1_2_11_42_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2022.138309"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2021.107869"},{"key":"e_1_2_11_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2022.114294"},{"key":"e_1_2_11_43_3","author":"Xie J.","year":"2022","journal-title":"Trends Biotech."},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj0960567"},{"key":"e_1_2_11_44_2","doi-asserted-by":"publisher","DOI":"10.1128\/aem.56.6.1960-1962.1990"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2023.05.010"},{"key":"e_1_2_11_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2021.12.012"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3525"},{"key":"e_1_2_11_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-018-0112-2"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3480"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11220"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-31171-0"},{"key":"e_1_2_11_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2023.108202"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09034-y"},{"key":"e_1_2_11_50_2","doi-asserted-by":"publisher","DOI":"10.1021\/nn405724x"},{"key":"e_1_2_11_50_3","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.9b02182"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2020.04.031"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-019-0236-5"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0031951"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.833040"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-021-00285-3"},{"key":"e_1_2_11_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2020.04.004"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201804310"},{"key":"e_1_2_11_56_2","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202105749"},{"key":"e_1_2_11_56_3","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202101487"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201700611"},{"key":"e_1_2_11_57_2","doi-asserted-by":"publisher","DOI":"10.7150\/thno.44564"},{"key":"e_1_2_11_57_3","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201908185"},{"key":"e_1_2_11_57_4","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1807"},{"key":"e_1_2_11_57_5","doi-asserted-by":"publisher","DOI":"10.7150\/thno.50741"},{"key":"e_1_2_11_57_6","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201903761"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.8.4747"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.0c03776"},{"key":"e_1_2_11_59_2","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12429"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5b07828"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compositesb.2023.111047"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-022-00733-z"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-018-0333-1"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06137-w"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2080-8"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-30722-9"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-021-00658-3"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2022.01.024"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202003390"},{"key":"e_1_2_11_69_2","first-page":"12","author":"Mu\u00f1oz\u2010Garach A.","year":"2020","journal-title":"Nutrients"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2022.07.002"},{"key":"e_1_2_11_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2022.100881"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-022-00410-w"},{"key":"e_1_2_11_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2023.02.002"},{"key":"e_1_2_11_71_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2023.01.021"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2023.02.013"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-023-01973-5"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12401"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12404"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-01735-1"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2024.100948"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/2730472"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41385-021-00392-9"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-019-03052-1"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2024.01.011"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micres.2014.09.006"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12162"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12182"},{"key":"e_1_2_11_85_1","first-page":"2991453","volume":"8","author":"Zu M.","journal-title":"Adv. Mater."},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.9b06330"},{"key":"e_1_2_11_86_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.0c06134"},{"key":"e_1_2_11_86_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2018.11.007"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2024.102196"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41413-023-00313-5"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0812874106"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-022-00886-2"},{"key":"e_1_2_11_90_2","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12395"},{"key":"e_1_2_11_90_3","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12189"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.1002\/biot.201700695"},{"key":"e_1_2_11_91_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2018.11.002"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.20517\/evcna.2022.04"},{"key":"e_1_2_11_92_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.03.010"},{"key":"e_1_2_11_92_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2022.107983"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12283"},{"key":"e_1_2_11_93_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2022.107934"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2023.10.027"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-022-00797-x"},{"key":"e_1_2_11_95_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2023.05.012"},{"key":"e_1_2_11_96_1","first-page":"93","volume":"5","author":"Liu H.","year":"2024","journal-title":"Biomater. Transl."},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2023.09.005"},{"key":"e_1_2_11_97_2","doi-asserted-by":"publisher","DOI":"10.1007\/s42242-022-00226-y"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-023-04050-5"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.10.029"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.01.031"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2757"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01525"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2008.02.016"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2010.10.103"},{"key":"e_1_2_11_105_1","doi-asserted-by":"publisher","DOI":"10.1080\/09637486.2022.2078285"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2008.00224.x"},{"key":"e_1_2_11_107_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2005-0625"},{"key":"e_1_2_11_108_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2012.01856.x"},{"key":"e_1_2_11_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2014.06.014"},{"key":"e_1_2_11_110_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2009.02230.x"}],"container-title":["Small Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smsc.202400474","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T02:03:33Z","timestamp":1743905013000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/smsc.202400474"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,23]]},"references-count":191,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1002\/smsc.202400474"],"URL":"https:\/\/doi.org\/10.1002\/smsc.202400474","archive":["Portico"],"relation":{},"ISSN":["2688-4046","2688-4046"],"issn-type":[{"value":"2688-4046","type":"print"},{"value":"2688-4046","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,23]]},"article-number":"2400474"}}