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LIP\u2010HA44700\u2010Im are assessed for their uptake and biological activity on respiratory effectors that are related to CD44 expression and compared to undecorated liposomes (LIP). LIP\u2010HA44700\u2010Im uptake is significantly higher than that of LIP, and most of the internalized LIP\u2010HA44700\u2010Im are colocalized with cellular endosomes. LIP\u2010HA44700\u2010Im also reduce lung fibroblasts viability. After 24\u2009h, LIP\u2010HA44700\u2010Im are able to impair collagen 1a1 release and c\u2010Abl phosphorylation. Based on in\u2009vitro data, it has been assessed whether the intratracheal administration of LIP\u2010HA44700\u2010Im is able to prevent lung fibrosis in a mouse bleomycin model. The local administration of LIP\u2010HA44700\u2010Im is associated with a significant decrease in alveolar inflammation, lung fibrosis, collagen deposition, and TGF\u2010\u03b2 expression. LIP\u2010HA44700\u2010Im target and deliver imatinib to lung pathogenic cells in\u2009vitro and represent a promising therapeutic option for the local treatment of fibrogenic lung disorders, although further development is required. 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