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CeNPs (size, 27.5\u2009nm) with a fluorite crystallization structure are synthesized and subjected to X\u2010ray diffraction and gas adsorption analyzes. Synthesized CeNPs exhibit Ce<jats:sup>3+<\/jats:sup> and Ce<jats:sup>4+<\/jats:sup> on their surfaces, a specific surface area within the standard range, and self\u2010regenerative antioxidative functions. Synthesized CeNPs reduce reactive oxygen species (ROS) levels and exhibit good biocompatibility in muscle satellite (C2C12) cells. According to Rotarod, tensile, and histological analyzes, CeNP treatment once per week in 4\u2010HC\u2010treated mice markedly increases muscle strength and the cross\u2010sectional muscle tissue area relative to that in control mice. Next\u2010generation sequencing identifies CILP2 as a key differentially upregulated gene common to aging muscle tissues and satellite cells in the presence of ROS. Quantitative polymerase chain reaction and western blotting confirm CILP2, Serpine1, phospho\u2010p21, Atrogin\u20101, and Cxcl10 downregulation in CeNP\u2010treated mice (compared with 4\u2010HC\u2010treated mice); in\u2009vitro CILP2 knockdown results in Serpine1 and phospho\u2010p21 downregulation. These findings confirm the long\u2010acting effects of CeNPs against sarcopenia in older individuals.<\/jats:p>","DOI":"10.1002\/smsc.202500208","type":"journal-article","created":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T12:59:57Z","timestamp":1750942797000},"source":"Crossref","is-referenced-by-count":3,"title":["Cerium Oxide Nanoparticles Achieve Long\u2010Lasting Senescence Inhibition in an Aging Mouse Model of Sarcopenia via Reactive Oxygen Species Scavenging and CILP2 Downregulation"],"prefix":"10.1002","volume":"5","author":[{"given":"Wei\u2010Chih","family":"Lien","sequence":"first","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation National Cheng Kung University Hospital College of Medicine National Cheng Kung University  No. 138, Sheng Li Road Tainan 704 Taiwan (R.O.C.)"},{"name":"Department of Physical Medicine and Rehabilitation College of Medicine  No. 1, University Road Tainan 701 Taiwan (R.O.C.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Ling","family":"Yu","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering College of Medicine and College of Engineering National Taiwan University  No. 1, Sec. 4, Roosevelt Rd Taipei 106 Taiwan (R.O.C.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya\u2010Jyun","family":"Liang","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering College of Medicine and College of Engineering National Taiwan University  No. 1, Sec. 4, Roosevelt Rd Taipei 106 Taiwan (R.O.C.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia\u2010Yih","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Anatomy College of Medicine National Cheng Kung University  No. 1, University Road Tainan 701 Taiwan (R.O.C.)"},{"name":"Institute of Basic Medical Sciences College of Medicine National Cheng Kung University  No. 1, University Road Tainan 701 Taiwan (R.O.C.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang\u2010Chen","family":"Lin","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering College of Medicine and College of Engineering National Taiwan University  No. 1, Sec. 4, Roosevelt Rd Taipei 106 Taiwan (R.O.C.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huei\u2010Cih","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation College of Medicine  No. 1, University Road Tainan 701 Taiwan (R.O.C.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2994-6671","authenticated-orcid":false,"given":"Feng\u2010Huei","family":"Lin","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering College of Medicine and College of Engineering National Taiwan University  No. 1, Sec. 4, Roosevelt Rd Taipei 106 Taiwan (R.O.C.)"},{"name":"Institute of Biomedical Engineering and Nanomedicine National Health Research Institutes  No. 35, Keyan Road, Zhunan Miaoli 350 Taiwan (R.O.C.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4692-4917","authenticated-orcid":false,"given":"Hui\u2010Min","family":"David Wang","sequence":"additional","affiliation":[{"name":"Graduate Institute of Biomedical Engineering National Chung Hsing University  No. 145, Xingda Rd., South Dist. 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