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This viewpoint considers the crossing of boundaries of progress in the nanotechnology of nanoscale pigments with environmental, animal, and human health and emphasizes the significance of collaborative activity. Traditional perspectives explain the distribution of pigment history, while the nanotechnology of today's accessibility poses problems regarding utilization, toxicities, and interactions with the environment. Through discussions of environmental pathways, health determinants, and regulatory insufficiencies, this work makes evident that pigments are critical both as emerging contaminant's and as innovation drivers. The necessary advancements in exposure minimization and sustainable practices are discussed as well, giving insight on benign\u2010by\u2010design techniques and circular economy solutions. Expanding the discussion of the existing knowledge and the gap where the \u00b4One Health\u00b4 concept can be applied in physiochemical properties of pigments as well as governance, this work offers an approach to enabling risk while enhancing invention. 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