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Therefore, targeted therapy for cartilage is becoming more and more promising. Exosomes, natural cellular derivatives, have emerged as promising therapeutic vectors owing to their inherent biocompatibility, superior biomatrix penetration capabilities, and therapeutic efficacy in cartilage regeneration. Precise targeting of cartilage tissues can be achieved through specific construction strategies, showing potential for treating cartilage\u2010related diseases. However, a review of cartilage\u2010targeted exosomes is still lacking. Previous studies have merely categorized chondrocytes under the broader group of osteocytes, regarding them only as a supplementary component of bone\u2010targeted therapy, or have been limited to a single modification technique. This review specifically focus on cartilage\u2010targeted exosomes, systematically integrating two modification methods\u2014direct surface modification and parental cell engineering\u2014and highlights translational applications in disease contexts. 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