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This study develops a microneedle (MN) system integrated with copper nanocluster\u2010decorated magnesium silicate nanoparticles (denoted as MS@Cu MNs), which enables efficient diabetic wound healing via a synergistic multimechanism strategy. Leveraging the unique enzyme\u2010mimetic activity of copper nanoclusters (CuNCs) and the angiogenic properties of magnesium silicate nanoparticles (MS NPs), the engineered MS@Cu nanocomposites demonstrate: 1) broad\u2010spectrum antibacterial efficacy (sterilization rate &gt;99.9%), 2) microenvironment regulation via simultaneous hypoxia mitigation, ROS scavenging, and angiogenesis promotion, and 3) enhanced fibroblast proliferation and migration through PI3K\u2010AKT signaling pathway activation. The MN system using \u03b3\u2010polyglutamic acid (\u03b3PGA) as a matrix exhibits both superior mechanical strength and excellent biodegradability. In vivo studies demonstrated accelerated closure of infected diabetic wounds in animal models, with histological analysis revealing robust mature collagen deposition and tissue regeneration. This study develops an integrated strategy for chronic diabetic wound management, combining potentiated antibacterial activity with targeted microenvironment remodeling.<\/jats:p>","DOI":"10.1002\/smsc.202500442","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T09:15:03Z","timestamp":1763543703000},"source":"Crossref","is-referenced-by-count":5,"title":["Copper Nanocluster\u2010Decorated Magnesium Silicate\u2010Based Microneedle Enhances Antimicrobial Effects and Tissue Remodeling for Diabetic Wounds"],"prefix":"10.1002","volume":"6","author":[{"given":"Shuo","family":"Tan","sequence":"first","affiliation":[{"name":"Center for Orthopaedic Science and Translational Medicine Department of Orthopaedics Shanghai Tenth People's Hospital, School of Medicine Tongji University  Shanghai 200072 P. R. 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