{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T17:23:01Z","timestamp":1790356981482,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Zhejiang Natural Science Foundation","doi-asserted-by":"publisher","award":["LY23H300002"],"award-info":[{"award-number":["LY23H300002"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFD1800102"],"award-info":[{"award-number":["2023YFD1800102"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Small Science"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:p>\n                    The rapid escalation of antibiotic resistance has profoundly limited the effectiveness of conventional antimicrobial therapies, underscoring an urgent need for alternative antibacterial strategies. In this study, we present an innovative, antibiotic\u2010free dual\u2010action antibacterial platform designed to effectively eradicate recalcitrant methicillin\u2010resistant\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    (MRSA) biofilm\u2010associated infections. Building upon conventional antimicrobial photodynamic therapy (APDT), a chemiluminescence\u2010based activation system is introduced to enable in\u2009situ APDT excitation, thereby overcoming the limited tissue penetration depth associated with external light sources. The byproduct CO\n                    <jats:sub>2<\/jats:sub>\n                    gas not only disrupts the biofilm structure but also provides physical propulsion to drug\u2010loaded nanocarriers, facilitating the deep and uniform penetration of antimicrobial agents into the biofilm. Furthermore, hypericin functions not only as a photosensitizer that induces reactive oxygen species generation and oxidative stress in MRSA but also as an inhibitor of cystathionine \u03b2\u2010synthase (CBS), thereby disrupting the bacterial H\n                    <jats:sub>2<\/jats:sub>\n                    S\u2010based self\u2010defense pathway. Collectively, the in\u2009situ activation of photosensitizers via chemiluminescence represents a novel antibacterial strategy that overcomes the intrinsic limitations of light penetration. By enabling precise, localized activation of multiple antibacterial mechanisms, this approach offers a promising therapeutic solution for the treatment of recalcitrant MRSA infections and related diseases, with strong potential for clinical translation.\n                  <\/jats:p>","DOI":"10.1002\/smsc.202500618","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T19:35:40Z","timestamp":1773430540000},"source":"Crossref","is-referenced-by-count":3,"title":["A Chemiluminescence\u2010Activated Photodynamic Platform to Penetrate MRSA Biofilms and Counteract H\n                    <sub>2<\/sub>\n                    S\u2010Mediated Defense"],"prefix":"10.1002","volume":"6","author":[{"given":"WeiYe","family":"Ren","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences The First Affiliated Hospital of Zhejiang Chinese Medical University  Hangzhou 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