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Despite extensive work on inorganic biomaterials, layered silicate nanoclays remain a comparatively underexplored class of 2D systems. Here, we report an optimized hydrothermal method for the tunable fabrication of 2D layered magnesium nanosilicates (nSi). This approach yields disc\u2010like nanoclays with lateral dimensions of \u2009~20\u201350\u2009nm and thickness of ~1\u20132\u2009nm. The nanosilicates exhibit rapid cellular internalization, controlled therapeutic release in vitro, and the ability to form shear\u2010thinning, thixotropic gels. Proteomic analyses indicate the formation of a protein corona enriched in factors associated with blood coagulation, consistent with in vitro clotting assays showing a concentration\u2010dependent reduction in clotting time, with decreases of ~50% at higher doses. In an in vivo rat liver\u2010laceration model, nanosilicate treatment reduced clotting time by ~75% and blood loss by ~45%, compared with controls. Collectively, these findings establish a tunable route for fabricating 2D\u2010layered magnesium nanosilicates and suggest their potential utility in hemostasis and wound\u2010management applications.<\/jats:p>","DOI":"10.1002\/smsc.70374","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T10:22:18Z","timestamp":1788949338000},"source":"Crossref","is-referenced-by-count":0,"title":["Tunable Fabrication of 2D\u2010Layered Magnesium Nanosilicates With Hemostatic Properties"],"prefix":"10.1002","volume":"6","author":[{"given":"Anna L.","family":"Keller","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering College of Engineering Texas A&amp;M University  College Station Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9704-0495","authenticated-orcid":false,"given":"Kanwar Abhay","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Biomedical 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