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However, delivering NO in a controlled and sustained manner is challenging due to its short half\u2010life of less than 5\u2009s. To address this challenge, we synthesized polyacrylamide (PAAm) hydrogels loaded with selenium nanoparticles (SeNPs) or polydopamine\u2010coated selenium nanoparticles (Se@PDA NPs), which can catalytically generate NO from both endogenous and exogenous NO donors. Structural characterization confirmed that nanoparticle loading did not alter the intrinsic properties of the PAAm\u2010gel. By adjusting the concentration of NPs loaded within the hydrogels, tunable NO generation was achieved. Both Se\u2010gel and Se@PDA\u2010gel exhibited sustained NO generation, with Se@PDA\u2010gel demonstrating superior recyclability and stability, even after long\u2010term storage under various conditions. The hydrogels exhibited excellent biocompatibility, and their biological activity was validated by elevated interleukin\u201010 (IL\u201010)\u00a0and \u03b1\u2010smooth muscle actin (\u03b1\u2010SMA) expression, indicating anti\u2010inflammatory effects and potential for wound healing, respectively. These findings establish Se@PDA\u2010gel as a promising platform for controlled and sustained NO delivery, offering therapeutic potential in wound healing and anti\u2010inflammatory therapies, particularly for cardiovascular and infectious diseases.<\/jats:p>","DOI":"10.1002\/smsc.70409","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T05:37:32Z","timestamp":1790055452000},"source":"Crossref","is-referenced-by-count":0,"title":["Catalytic Nitric Oxide\u2010Generating Selenium Nanoparticle\u2010Loaded Hydrogels With Anti\u2010Inflammatory and Pro\u2010Wound\u2010Healing Properties"],"prefix":"10.1002","volume":"6","author":[{"given":"Shu","family":"Geng","sequence":"first","affiliation":[{"name":"School of Chemical Engineering and Australian Centre for Nanomedicine (ACN) The University of New South Wales (UNSW Sydney)  Sydney NSW 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