{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T05:53:49Z","timestamp":1791438829709,"version":"4.3.3"},"reference-count":100,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100011033","name":"Agencia Estatal de Investigaci\u00f3n","doi-asserted-by":"publisher","award":["CEX2023\u2010001263\u2010S"],"award-info":[{"award-number":["CEX2023\u2010001263\u2010S"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Small Science"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:p>\n                    Boron Neutron Capture Therapy (BNCT) relies on the accumulation of boron\u201010 within tumor cells to induce highly localized cytotoxicity upon neutron irradiation. The development of boron delivery systems with high boron content, biocompatibility, and efficient cellular uptake remains a critical challenge. Herein, we report the design and synthesis of unprecedented fullerene\u2013boron cluster hybrids that integrate the multivalent scaffold of [60]fullerene with anionic boron clusters. Two [60]fullerene hexakis\u2010adducts bearing twelve peripheral cobaltabisdicarbollide (COSAN) or\n                    <jats:italic>closo<\/jats:italic>\n                    \u2010dodecaborate boron clusters have been prepared through a Cu(I)\u2010catalyzed azide\u2013alkyne cycloaddition strategy. The resulting nanostructures incorporate up to 216 boron atoms while preserving the structural integrity of both the fullerene core and the anionic boron clusters. Comprehensive spectroscopic and electrochemical characterization confirms the successful formation of the hybrids. To enable biological evaluation, the compounds are formulated into liposomes, showing excellent cytocompatibility and efficient cellular internalization in mouse embryonic fibroblasts and Cal33 human head and neck cancer cells. Confocal microscopy reveals predominant endolysosomal localization without significant cytotoxicity at therapeutically relevant boron concentrations. These results establish fullerene\u2013boron cluster conjugates as a new class of boron\u2010rich nanomaterials and highlight their potential as boron delivery agents for future BNCT studies.\n                  <\/jats:p>","DOI":"10.1002\/smsc.70413","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T05:22:34Z","timestamp":1791436954000},"source":"Crossref","is-referenced-by-count":0,"title":["[60]Fullerene\u2013Cluster Hybrids as Boron\u2010Dense Delivery Nanoplatforms"],"prefix":"10.1002","volume":"6","author":[{"given":"Jennifer","family":"Patino\u2010Alonso","sequence":"first","affiliation":[{"name":"Departamento de Qu\u00edmica Org\u00e1nica Facultad de Qu\u00edmica Universidad Complutense  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9867-3614","authenticated-orcid":false,"given":"M\u00f3nica","family":"Mu\u00f1oz\u2010\u00dabeda","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica F\u00edsica Facultad de Qu\u00edmica Universidad Complutense  Madrid Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Hospital Doce de Octubre (imas12)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8131-6063","authenticated-orcid":false,"given":"Iv\u00e1n","family":"L\u00f3pez\u2010Montero","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica F\u00edsica Facultad de Qu\u00edmica Universidad Complutense  Madrid Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Hospital Doce de Octubre (imas12)  Madrid Spain"},{"name":"Instituto Pluridisciplinar Universidad Complutense  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Jos\u00e9","family":"Ruiz\u2010Maga\u00f1a","sequence":"additional","affiliation":[{"name":"Instituto de Biopatolog\u00eda y Medicina Regenerativa Centro de Investigaci\u00f3n Biom\u00e9dica Universidad de Granada  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Ruiz\u2010Ruiz","sequence":"additional","affiliation":[{"name":"Instituto de Biopatolog\u00eda y Medicina Regenerativa Centro de Investigaci\u00f3n Biom\u00e9dica Universidad de Granada  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Porras","sequence":"additional","affiliation":[{"name":"Departamento de F\u00edsica At\u00f3mica, Molecular y Nuclear Facultad de Ciencias Universidad de Granada  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miquel","family":"Nuez\u2010Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Institut de Ci\u00e8ncia de Materials de Barcelona (ICMAB\u2010CSIC)  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