{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T08:54:52Z","timestamp":1776848092881,"version":"3.51.2"},"reference-count":46,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,10,22]],"date-time":"2021-10-22T00:00:00Z","timestamp":1634860800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81872473"],"award-info":[{"award-number":["81872473"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small Methods"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cisplatin has been used as standard regimen for hepatocellular carcinoma (HCC), but its therapeutic efficacy is greatly limited by the drug resistance. Cisplatin alone cannot achieve an ideal therapeutic outcome. Herein, a dual threat hybrid artemisinin platinum (ArtePt) is synthesized to combine chemodynamic therapy (CDT) with chemotherapy. On the one hand, artesunate can react with intracellular ferrous ion to generate reactive oxygen species (ROS) via Fenton reaction for CDT. On the other hand, cisplatin can target DNA for chemotherapy. However, GSH in cancer cells can effectively consume free radicals and detoxify cisplatin simultaneously, which compromised the efficacy of CDT and chemotherapy. Hence, an amphiphilic polymer with an iodine atom in the side chain is designed and encapsulated ArtePt to form NP(ArtePt). This iodine containing polymer NP(ArtePt) can effectively deplete intracellular GSH via an Iodo\u2010Click reaction, thereby enhancing the effect of CDT as well as chemotherapy. Thereafter, a patient\u2010derived xenograft model of hepatic carcinoma (PDX<jats:sup>HCC<\/jats:sup>) is established to evaluate the therapeutic effect of NP(ArtePt), and a significant antitumor effect is achieved with NP(ArtePt). Overall, this study provides an effective strategy to combine CDT with chemotherapy to enhance the efficacy of cisplatin via Iodo\u2010Click reaction, opening a new avenue for the cancer treatment.<\/jats:p>","DOI":"10.1002\/smtd.202101047","type":"journal-article","created":{"date-parts":[[2021,10,22]],"date-time":"2021-10-22T14:20:56Z","timestamp":1634912456000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Enhanced Chemodynamic Therapy and Chemotherapy via Delivery of a Dual Threat ArtePt and Iodo\u2010Click Reaction Mediated Glutathione Consumption"],"prefix":"10.1002","volume":"5","author":[{"given":"Qiao","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Oncology Third Xiangya Hospital Central South University  Changsha Hunan 410013 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siqi","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Oncological Radiotherapy Hunan Academy of Traditional Chinese Medicine Affiliated Hospital  Changsha Hunan 410006 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Oncology Third Xiangya Hospital Central South University  Changsha Hunan 410013 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Long","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Oncology Third Xiangya Hospital Central South University  Changsha Hunan 410013 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuliang","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Oncology Third Xiangya Hospital Central South University  Changsha Hunan 410013 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oncology Third Xiangya Hospital Central South University  Changsha Hunan 410013 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of General Surgery China\u2010Japan Friendship Hospital  Beijing 100029 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6772-1273","authenticated-orcid":false,"given":"Haihua","family":"Xiao","sequence":"additional","affiliation":[{"name":"Beijing National Laboratory for Molecular Sciences State Key Laboratory of Polymer Physics and Chemistry Institute of Chemistry Chinese Academy of Sciences  Beijing 100190 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peiguo","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Oncology Third Xiangya Hospital Central South University  Changsha Hunan 410013 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,10,22]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e31820d944f"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/cas.13656"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.66.9689"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1039\/C2CS35259A"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2018.07.002"},{"key":"e_1_2_7_4_3","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19991210)83:6<866::AID-IJC34>3.0.CO;2-9"},{"key":"e_1_2_7_4_4","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2013.05.006"},{"key":"e_1_2_7_4_5","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2014.09.012"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.7.3070"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2018.10.092"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.8b01924"},{"key":"e_1_2_7_7_1","first-page":"307","volume":"62","author":"Kuppusamy P.","year":"2002","journal-title":"Cancer Res."},{"key":"e_1_2_7_8_1","first-page":"6885","volume":"52","author":"Meijer C.","year":"1992","journal-title":"Cancer Res."},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.9b13214"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-043015-123453"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2018.01.001"},{"key":"e_1_2_7_10_3","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201601967"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2017.02.009"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/med.21446"},{"key":"e_1_2_7_11_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2013.12.001"},{"key":"e_1_2_7_11_4","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201805664"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b03476"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2803"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201906024"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.8b00214"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2020.574614"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.7b04043"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.0c03781"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.5b00597"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04318-1"},{"key":"e_1_2_7_16_3","doi-asserted-by":"publisher","DOI":"10.1039\/C9TB00155G"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.0c14046"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.6b08933"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5NR04963F"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2018.11.039"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201912768"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.119498"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8CC06576D"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja5038269"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b12108"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/bcj.2014.45"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.6b04269"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2013.01.016"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.0c06190"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.09.028"}],"container-title":["Small Methods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smtd.202101047","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/smtd.202101047","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smtd.202101047","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T10:40:53Z","timestamp":1692873653000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/smtd.202101047"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,22]]},"references-count":46,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10.1002\/smtd.202101047"],"URL":"https:\/\/doi.org\/10.1002\/smtd.202101047","archive":["Portico"],"relation":{},"ISSN":["2366-9608","2366-9608"],"issn-type":[{"value":"2366-9608","type":"print"},{"value":"2366-9608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,22]]},"assertion":[{"value":"2021-09-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2101047"}}