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The development of innovative strategies for improving the adhesion efficiency of carriers is of high importance for the advancement of this field. Herein, a novel approach to achieving high adhesion efficiency of drug carriers is presented, where the accessibility of the carrier to the intestinal surface and its subsequent adhesion to the intestinal tissue are promoted by utilizing the thermodynamic tendency of the hydrophobic carrier and its dispersion solvent, triacetin, to be excluded from the aqueous environment. Drug carriers are fabricated using proteins, imparting multiple functions, including drug release and the removal of reactive oxygen species (ROS). Results of ex vivo studies indicate that this multifunctional protein\u2010based carrier, \u201cprotein micropatch,\u201d adheres to various mouse intestinal tissues, including the small intestine, colon, and inflamed colon, with high efficiency. Furthermore, protein micropatches, administered to mice via oral or rectal routes, successfully adhere to the intestinal tract. This approach and the highly functionalized carrier described in the study have the potential to significantly contribute to the development of bioadhesive carrier\u2010based drug delivery systems.<\/jats:p>","DOI":"10.1002\/smtd.202200153","type":"journal-article","created":{"date-parts":[[2022,4,23]],"date-time":"2022-04-23T08:14:36Z","timestamp":1650701676000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Superior Adhesion of a Multifunctional Protein\u2010Based Micropatch to Intestinal Tissue by Harnessing the Hydrophobic Effect"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2948-8786","authenticated-orcid":false,"given":"Hironori","family":"Yamazoe","sequence":"first","affiliation":[{"name":"Advanced Medical Devices Research Group Biomedical Research Institute National Institute of Advanced Industrial Science and Technology (AIST) 1\u20108\u201031 Midorigaoka Ikeda Osaka 563\u20138577 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chizuko","family":"Kominami","sequence":"additional","affiliation":[{"name":"Advanced Medical Devices Research Group Biomedical Research Institute National Institute of Advanced Industrial Science and Technology (AIST) 1\u20108\u201031 Midorigaoka Ikeda Osaka 563\u20138577 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroko","family":"Abe","sequence":"additional","affiliation":[{"name":"Cellular Function Analysis Research Group Health and Medical Research Institute National Institute of Advanced Industrial Science and Technology (AIST) 2217\u201014 Hayashi\u2010cho Takamatsu Kagawa 761\u20100395 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4,23]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2013.04.020"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2016.12.031"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6446(05)03489-6"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2017.08.005"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaa5657"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2005.07.001"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2015.07.033"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2016.10.026"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-3659(99)00228-X"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2005.10.017"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn3019865"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2017.10.045"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2017.04.036"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/9875298"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v11.i3.403"},{"key":"e_1_2_7_13_3","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.108.144451"},{"key":"e_1_2_7_14_1","doi-asserted-by":"crossref","first-page":"3475356","DOI":"10.1155\/2016\/3475356","volume":"2016","author":"da Silva L. 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