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Here, a highly efficient metal\u2010free CDT by using endoperoxide bridge\u2010containing artesunate as free radical\u2010generating substance is developed. A Pt(IV) prodrug (A\u2010Pt) containing two artesunate molecules in the axial direction is synthesized, which can be decomposed into cisplatin and artesunate under reducing intracellular environment in tumor cells. To improve the catalytic efficiency for Fenton reaction, a near\u2010infrared\u2010II (NIR\u2010II) photothermal agent IR1048 is incorporated to achieve a mild hyperthermia effect. By encapsulating the A\u2010Pt and IR1048 with human serum albumin, A\u2010Pt\u2010IR NP are formulated for efficient drug delivery in 4T1 tumor\u2010bearing mice. NIR\u2010II light irradiation of A\u2010Pt\u2010IR NP treated mice show accelerated Fenton reaction. In addition, A\u2010Pt\u2010IR NP could also induce strong immunogenic cell death, which effectively reverses the immunosuppressive tumor microenvironment, and augments antitumor immunity. This study demonstrates that A\u2010Pt\u2010IR NP are potent biodegradable NIR\u2010II active chemotherapy\/CDT nanomedicine for clinical translation.<\/jats:p>","DOI":"10.1002\/smtd.202200379","type":"journal-article","created":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T03:38:47Z","timestamp":1660793927000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["Near\u2010Infrared\u2010II Light Induced Mild Hyperthermia Activate Cisplatin\u2010Artemisinin Nanoparticle for Enhanced Chemo\/Chemodynamic Therapy and Immunotherapy"],"prefix":"10.1002","volume":"6","author":[{"given":"Guoliang","family":"Xiong","sequence":"first","affiliation":[{"name":"Department of Nephrology Shenzhen Traditional Chinese Medicine Hospital  Shenzhen 518033 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dakun","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Urology Shenzhen 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