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Exogenous electrical stimulation (ES) that is carried out by the conductive conduit regulates the biological behavior of Schwann cells (SCs). Meanwhile, a longitudinal surface structure counts to guide axonal growth to accelerate the end\u2010to\u2010end connection. Currently, there are no conduits equipped with both electrical conduction and axon\u2010guiding surface structure. Herein, a biodegradable, conductive poly(<jats:sc>l<\/jats:sc>\u2010lactide\u2010<jats:italic>co<\/jats:italic>\u2010caprolactone)\/graphene (PLCL\/GN) composite conduit is designed. The conduit with 20.96 \u00b1 1.26\u00a0MPa tensile strength has a micropatterned surface of 20\u00a0\u00b5m groove fabricated by microimprint technology and self\u2010assembled polydopamine (PDA). In vitro evaluation shows that the conduits with ES effectively stimulate the directional cell migration, adhesion, and elongation, and enhance neuronal expression of SCs. The rat sciatic nerve crush model demonstrates that the conductive micropatterned conduit with ES promotes the growth of myelin sheath, faster nerve regeneration, and 20\u2010fold functional recovery in vivo. These discoveries prove that the PLCL(G)\/PDA\/GN composite conduit is a promising tool for PNI treatment by providing the functional integration of physical guidance, biomimetic biological regulation, and bioelectrical stimulation, which inspires a novel therapeutic approach for nerve regeneration in the future.<\/jats:p>","DOI":"10.1002\/smtd.202200883","type":"journal-article","created":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T02:14:22Z","timestamp":1672798462000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":80,"title":["Polydopamine\u2010Decorated PLCL Conduit to Induce Synergetic Effect of Electrical Stimulation and Topological Morphology for Peripheral Nerve Regeneration"],"prefix":"10.1002","volume":"7","author":[{"given":"Shunyi","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery Zhongshan Hospital Fudan University  Shanghai 200032 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