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To enhance the treatment efficacy of SDT, the development of high\u2010efficiency and stable sonosensitizers are still needed. Herein, a defective homojunction porphyrin\u2010based metal\u2010organic framework (MOF) with greatly enhanced sonocatalytic ability is easily prepared and used for SDT of osteomyelitis infected by methicillin\u2010resistant Staphylococcus aureus (MRSA). Acetic acid and benzoic acid are chosen as modulators during the hydrothermal synthesis of porphyrin\u2010based MOF. It is found that the crystal structure of MOF shifts from PCN\u2010222 to PCN\u2010224 as the amount of acetic acid increases. Interestingly, the defective PCN (D\u2010PCN) contains a two\u2010phase homojunction structure of PCN\u2010222\/PCN\u2010224. The sonocatalytic reactive oxygen species production presents a volcano\u2010type trend with increased acetic acid, among which D\u2010PCN\u20102 with more content of PCN\u2010224 has the best sonocatalytic antibacterial ability. The reduced band gap introduced a defect, and type\u2010II homojunction structures of D\u2010PCN\u20102 improve the separation of the ultrasound\u2010triggered electron hole, which significantly enhances the SDT effect. Through a mixed linker approach, this work develops a new defect\u2010induced homojunction MOF with great performance for SDT of MRSA\u2010infected osteomyelitis.<\/jats:p>","DOI":"10.1002\/smtd.202201248","type":"journal-article","created":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T02:21:47Z","timestamp":1671762107000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":74,"title":["Defective Homojunction Porphyrin\u2010Based Metal\u2010Organic Frameworks for Highly Efficient Sonodynamic Therapy"],"prefix":"10.1002","volume":"7","author":[{"given":"Yuxuan","family":"Zeng","sequence":"first","affiliation":[{"name":"Biomedical Materials Engineering Research Center Hubei Key Laboratory of Polymer Materials Ministry\u2010of\u2010Education Key Laboratory for the Green Preparation and Application of Functional Materials School of Materials Science &amp; Engineering Hubei University  Wuhan 430062 P. R. 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