{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T11:59:06Z","timestamp":1788263946639,"version":"build-2803163510"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T00:00:00Z","timestamp":1671494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22107095"],"award-info":[{"award-number":["22107095"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2804400"],"award-info":[{"award-number":["2022YFC2804400"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small Methods"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Androgenetic alopecia (AGA) is a transracial and cross\u2010gender disease worldwide with a youth\u2010oriented tendency, but it lacks effective treatment. The binding of androgen receptor (AR) and androgen plays an essential role in the occurrence and progression of AGA. Herein, novel proteolysis targeting chimera degrader of AR (AR\u2010PROTAC) is synthesized and integrated with dissolving microneedles (PROTAC\u2010MNs) to achieve AR destruction in hair follicles for AGA treatment. The PROTAC\u2010MNs possess adequate mechanical capabilities for precise AR\u2010PROTAC delivery into the hair follicle\u2010residing regions for AR degradation. After applying only once topically, the PROTAC\u2010MNs achieve an accelerated onset of hair regeneration as compared to the daily application of the first\u2010line topical drug minoxidil. Intriguingly, PROTAC\u2010MNs via single administration still realize superior hair regeneration in AGA recrudescence, which is the major drawback of minoxidil in clinical practice. With the degradation of AR, the PROTAC\u2010MNs successfully regulate the signaling cascade related to hair growth and activate hair follicle stem cells. Furthermore, the PROTAC\u2010MNs do not cause systemic toxicity or androgen deficiency\u2010related chaos in vivo. Collectively, these AR\u2010degrading dissolving microneedles with long\u2010lasting efficacy, one\u2010step administration, and high biocompatibility provide a great therapeutic potential for AGA treatment.<\/jats:p>","DOI":"10.1002\/smtd.202201293","type":"journal-article","created":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T16:07:05Z","timestamp":1671552425000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["PROTAC Degraders of Androgen Receptor\u2010Integrated Dissolving Microneedles for Androgenetic Alopecia and Recrudescence Treatment via Single Topical Administration"],"prefix":"10.1002","volume":"7","author":[{"given":"Ruxuan","family":"Wang","sequence":"first","affiliation":[{"name":"Institute of Pharmaceutics, College of Pharmaceutical Sciences Zhejiang University  Hangzhou 310058 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University  Hangzhou 310058 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anran","family":"Yuan","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutics, College of Pharmaceutical Sciences Zhejiang University  Hangzhou 310058 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weitong","family":"Hu","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutics, College of Pharmaceutical Sciences Zhejiang University  Hangzhou 310058 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8108-1698","authenticated-orcid":false,"given":"Chong","family":"Qin","sequence":"additional","affiliation":[{"name":"Key Laboratory of Marine Drugs Chinese Ministry of Education School of Medicine and Pharmacy Ocean University of China  Qingdao 266003 China"},{"name":"Marine Biomedical Research Institute of Qingdao  Qingdao 266071 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