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Logically, the combination of the two therapeutic modalities into radioimmunotherapy is promising to complement with each other for systemic elimination of cancer cells with high specificity, efficiency, and safety. Especially, RT\u2010induced immunogenic cell death (ICD) plays an imperative role in radioimmunotherapy to evoke systemic immune response against cancer, including elevating the immunity of tumor antigens, recruiting and activating antigen\u2010presenting cells, and priming cytotoxic T lymphocytes for tumoral infiltration and cancer cell eradication. This review first retrospects the origin and concept of ICD, summarizes the major damage\u2010associated molecular patterns and signaling pathways, and highlights the characteristics of RT\u2010induced ICD. Subsequently, therapeutic strategies enhancing RT\u2010induced ICD for radioimmunotherapy are reviewed from the perspectives of enhancing RT itself, combination with other treatments, and stimulating the holistic immune system. On the basis of these published research and underlying mechanism, this work attempts to forecast possible directions for RT\u2010induced ICD enhancement to promote clinical applications.<\/jats:p>","DOI":"10.1002\/smtd.202201401","type":"journal-article","created":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T00:56:15Z","timestamp":1677027375000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":94,"title":["Radiation\u2010Induced Immunogenic Cell Death for Cancer Radioimmunotherapy"],"prefix":"10.1002","volume":"7","author":[{"given":"Teng","family":"Liu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Radiation Medicine and Protection School of Radiation Medicine and Protection &amp; School for Radiological and Interdisciplinary Sciences (RAD\u2010X) Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions Suzhou Medical College Soochow University  Suzhou Jiangsu 215123 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei","family":"Pei","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Radiation Medicine and Protection School of Radiation Medicine and Protection &amp; 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