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However, current chemo\u2010immunotherapy strategies do not benefit most colorectal cancer patients and many triple\u2010negative breast cancer patients. Here, the design of a three\u2010in\u2010one nanoscale coordination polymer (NCP), OX\/GC\/CQ, comprising prodrugs of oxaliplatin (OX), gemcitabine (GC), and 5\u2010carboxy\u20108\u2010hydroxyquinoline (CQ) for triple\u2010modality chemo\u2010immunotherapy is reported. OX\/GC\/CQ exhibits optimal pharmacokinetics and enhanced particle accumulation and drug release in acidic tumor tissues, wherein CQ greatly enhances immunogenic cell death induced by OX\/GC and downregulates programmed cell death\u2010ligand 1 \u00a0expression in cancer cells. Consequently, OX\/GC\/CQ efficiently promotes infiltration and activity of cytotoxic T lymphocytes, while decreasing the proportion of immunosuppressive regulatory T cells. Intravenous injection of OX\/GC\/CQ reduces the growth of colorectal carcinoma and triple\u2010negative breast cancer, prevents metastasis to lungs, and extends mouse survival by 30\u201340 days compared to free drugs. This work highlights the potential of NCPs in co\u2010delivering synergistic chemo\u2010immunotherapeutics for the treatment of advanced and aggressive cancers.<\/jats:p>","DOI":"10.1002\/smtd.202201437","type":"journal-article","created":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T15:07:45Z","timestamp":1673622465000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["RETRACTED: A Three\u2010in\u2010One Nanoscale Coordination Polymer for Potent Chemo\u2010Immunotherapy"],"prefix":"10.1002","volume":"7","author":[{"given":"Jing","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Chemistry University of Chicago  Chicago IL 60637 USA"},{"name":"Department of Radiation and Cellular Oncology and the Ludwig Center for Metastasis Research University of Chicago  Chicago IL 60637 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