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Herein, a metal\u2013organic framework\u2010derived Bi<jats:sub>2<\/jats:sub>S<jats:sub>3<\/jats:sub>\/FeS<jats:sub>2<\/jats:sub> heterojunction (BFS) is synthesized, and the materials\u2013microorganism interface is further constructed. Through interfacial electron transfer, electrons are transferred from the bacteria to the BFS surface, disrupting the balance of the bacterial electron transport chain and inhibiting the metabolic activity of the bacteria. Moreover, BFS has enzyme\u2010like (oxidase and peroxidase) properties and can produce a large amount of reactive oxygen species to kill additional bacteria. In vitro antibacterial results show that the antibacterial efficiency of BFS against both <jats:italic>Staphylococcus aureus<\/jats:italic> and <jats:italic>Escherichia coli<\/jats:italic> reaches more than 99.9% after 4\u00a0h of co\u2010culture under dark conditions. Meanwhile, in vivo experiments show that BFS can effectively kill bacteria and promote wound healing. This work shows that BFS could be a novel, effective nanomaterial for the treatment of bacterial infections by constructing the materials\u2013microorganism interface.<\/jats:p>","DOI":"10.1002\/smtd.202201618","type":"journal-article","created":{"date-parts":[[2023,5,6]],"date-time":"2023-05-06T09:55:26Z","timestamp":1683366926000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Metal\u2013Organic Framework\u2010Derived Homologous Sulfide Heterojunction for Robust Enzyme\u2010Like Self\u2010Driven Bacteria\u2010Killing through Enhanced Electron Transfer"],"prefix":"10.1002","volume":"7","author":[{"given":"Hu","family":"Wei","sequence":"first","affiliation":[{"name":"Biomedical Materials Engineering Research Center Hubei Key Laboratory of Polymer Materials Ministry\u2010of\u2010Education Key Laboratory for the Green Preparation and Application of Functional Materials School of Materials Science &amp; Engineering Hubei University  Wuhan 430062 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Luo","sequence":"additional","affiliation":[{"name":"Biomedical Materials Engineering Research Center Hubei Key Laboratory of Polymer Materials Ministry\u2010of\u2010Education Key Laboratory for the Green Preparation and Application of Functional Materials School of Materials Science &amp; 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