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However, there are still some patients that cannot be identified by FR\u2010based CTC detection. And studies comparing the characteristics between true positive (TP) and false negative (FN) patients are few. Thus, the study comprehensively analyzes the clinicopathological characteristics of FN and TP patients in the current study. According to inclusion and exclusion criteria, 3420 patients are enrolled. Combining the pathological diagnosis with CTC results, patients are divided into FN and TP groups, and clinicopathological characteristics are compared between two groups. Compared with TP patients, FN patients have smaller tumor, early T stage, early pathological stage, and without lymph node metastasis. Epidermal growth factor receptor (EGFR) mutation status is different between FN and TP group. And this result is also demonstrated in lung adenocarcinoma subgroup but not in lung squamous cell carcinoma subgroup. Tumor size, T stage, pathological stage, lymph node metastasis, and <jats:italic>EGFR<\/jats:italic> mutation status may influence the accuracy of FR\u2010based CTC detection in lung cancer. However, further prospective studies are needed to confirm the findings.<\/jats:p>","DOI":"10.1002\/smtd.202300055","type":"journal-article","created":{"date-parts":[[2023,6,18]],"date-time":"2023-06-18T06:34:33Z","timestamp":1687070073000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Identify the Clinicopathological Characteristics of Lung Carcinoma Patients Being False Negative in Folate Receptor Based Circulating Tumor Cell Detection"],"prefix":"10.1002","volume":"7","author":[{"given":"Siming","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery Shanghai Pulmonary Hospital School of Medicine Tongji University  Shanghai 200433 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Shanghai Pulmonary Hospital School of Medicine Tongji University  Shanghai 200433 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junjie","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Shanghai Pulmonary Hospital School of Medicine Tongji University  Shanghai 200433 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinnan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Shanghai Pulmonary Hospital School of Medicine Tongji University  Shanghai 200433 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linsong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Shanghai Pulmonary Hospital School of Medicine Tongji University  Shanghai 200433 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Shanghai Pulmonary Hospital School of Medicine Tongji University  Shanghai 200433 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Shanghai Pulmonary Hospital School of Medicine Tongji University  Shanghai 200433 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuming","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Shanghai Pulmonary Hospital School of Medicine Tongji University  Shanghai 200433 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhemin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Shanghai Pulmonary Hospital School of Medicine Tongji University  Shanghai 200433 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benting","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Pathology Zhongshan Hospital Fudan University  Shanghai 200032 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Pathology Shanghai First Maternity and Infant Hospital School of Medicine Tongji University  Shanghai 200092 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1290-6665","authenticated-orcid":false,"given":"Yang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Shanghai Pulmonary Hospital School of Medicine Tongji University  Shanghai 200433 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,6,17]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21654"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.202504"},{"key":"e_1_2_9_4_1","first-page":"146","volume":"14","author":"Ashworth T. 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