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Long\u2010term use of antibiotics may predispose bacteria to develop resistance. Here, CuCeO<jats:italic><jats:sub>x<\/jats:sub><\/jats:italic> material is applied to treat infectious bacterial osteomyelitis using microwave (MW)\u2010assisted bacterial killing. Heat generation occurs as a result of the dielectric properties of the material under MW irradiation, and the material generates reactive oxygen species (ROS) under MW irradiation. Heat and ROS increase the thermal sensitivity and permeability of bacterial cell membranes, and the released copper ions easily penetrate the bacterial membrane and react with H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> to produce a toxic hydroxyl group inside the bacteria, leading to the bacteria's eventual death. This is due to the synergistic effect of the MW thermal effect, ROS, and the breaking of the equilibrium within the bacteria. CuCeO<jats:italic><jats:sub>x<\/jats:sub><\/jats:italic> can effectively treat osteomyelitis caused by <jats:italic>Staphylococcus aureus<\/jats:italic>\u00a0using MW irradiation. This study can safely and effectively address the challenge of deep tissue infections by shedding light on non\u2010invasive antimicrobial systems and using MW thermal therapy and MW dynamics to achieve therapeutic results.<\/jats:p>","DOI":"10.1002\/smtd.202300203","type":"journal-article","created":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T19:51:16Z","timestamp":1682711476000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Cu\uf8ffCe\uf8ffO Bimetallic Oxide Rapidly Treats <i>Staphylococcus aureus<\/i>\u2010Infected Osteomyelitis through Microwave Strengthened Microwave Catalysis and Fenton\u2010Therapy"],"prefix":"10.1002","volume":"7","author":[{"given":"Wenchan","family":"Sun","sequence":"first","affiliation":[{"name":"Biomedical Materials Engineering Research Center Hubei Key Laboratory of Polymer Materials Ministry\u2010of\u2010Education Key Laboratory for the Green Preparation and Application of Functional Materials School of Materials Science &amp; Engineering Hubei University  Wuhan 430062 P. 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