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In this study, seamless adhesive biomimetic periosteum patches (HABP\/Sr\u2010PLA) were prepared to fill microcracks in defective bone via interfacial self\u2010assembly induced by Sr ions mediated metal\u2010ligand interactions among pamidronate disodium\u2010modified hyaluronic acid (HAPD), black phosphorus (BP), and hydrophilic polylactic acid (PLA). In vitro, HABP\/Sr\u2010PLA exhibited excellent self\u2010healing properties, seamlessly filled bone microcracks, and significantly enhanced osteogenesis and angiogenesis. Furthermore, in a rat cranial defect model, HABP\/Sr\u2010PLA was demonstrated to significantly promote the formation of blood vessels and new bone under mild 808 nm photothermal stimulation (42.8 \u00b0C), and the highest protein expression of CD31 and OPN was five times higher than that of the control group and other groups. Therefore, the proposed seamless microcrack\u2010filled bionic periosteum patch is a promising clinical strategy for promoting bone repair.<\/jats:p>","DOI":"10.1002\/smtd.202300370","type":"journal-article","created":{"date-parts":[[2023,6,25]],"date-time":"2023-06-25T13:27:13Z","timestamp":1687699633000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Seamlessly Adhesive Bionic Periosteum Patches Via Filling Microcracks for Defective Bone Healing"],"prefix":"10.1002","volume":"7","author":[{"given":"Shu","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopaedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine  Shanghai 200025 P. R. 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