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Tissue adhesives have emerged as a promising alternative to suturing for mitigating postoperative complications. However, conventional water\u2010soluble adhesives suffer formidable challenges in sealing penetrating corneal wounds due to dilution or loss in a moist environment. Inspired by the robust adhesion of mussels in aquatic conditions, an injectable photocurable bioadhesive hydrogel (referred to as F20HD5) composed of polyether F127 diacrylate and dopamine\u2010modified hyaluronic acid methacrylate is developed for sutureless closure of corneal full\u2010thickness wounds. F20HD5 exhibits high transparency, wound\u2010sealing ability, proper viscosity, biodegradability, and excellent biocompatibility. It allows in situ cross\u2010linking via visible light, thereby providing sufficient mechanical strength and adhesiveness. In vivo, the adhesive hydrogel effectively closed penetrating linear corneal incisions and corneal injuries with minimal tissue loss in rabbits. During the 56\u2010day follow\u2010up, the hydrogel facilitates the repair of the injured corneas, resulting in more symmetrical curvatures and less scarring in distinction to the untreated control. Thus, bioinspired hydrogel holds promise as an effective adhesive for sealing full\u2010thickness corneal wounds.<\/jats:p>","DOI":"10.1002\/smtd.202300996","type":"journal-article","created":{"date-parts":[[2023,11,25]],"date-time":"2023-11-25T01:19:46Z","timestamp":1700875186000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Photocurable and Temperature\u2010Sensitive Bioadhesive Hydrogels for Sutureless Sealing of Full\u2010Thickness Corneal Wounds"],"prefix":"10.1002","volume":"8","author":[{"given":"Qian","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat\u2010sen University  Guangzhou 510623 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat\u2010sen University  Guangzhou 510623 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Yu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat\u2010sen University  Guangzhou 510623 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po\u2010Han","family":"Fang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat\u2010sen University  Guangzhou 510623 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat\u2010sen University  Guangzhou 510623 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Du","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat\u2010sen University  Guangzhou 510623 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihua","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat\u2010sen University  Guangzhou 510623 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalian","family":"He","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat\u2010sen University  Guangzhou 510623 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Bai","sequence":"additional","affiliation":[{"name":"Guangdong Engineering Technology Research Centre for Functional Biomaterials School of Materials Science and Engineering SunYat\u2010sen University  Guangzhou 510006 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saiqun","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat\u2010sen University  Guangzhou 510623 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5756-5414","authenticated-orcid":false,"given":"Jin","family":"Yuan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat\u2010sen University  Guangzhou 510623 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,23]]},"reference":[{"key":"e_1_2_8_1_1","volume-title":"Stat Pearls","author":"Willmann D.","year":"2021"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1442-9071.2000.00351.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2006.10.039"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(02)01078-3"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ceo.12635"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/112067210801800114"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(99)00020-6"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1968.00980050647013"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000001459"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.7b17054"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aav1281"},{"key":"e_1_2_8_9_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.07.001"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/02713680701767876"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2008.11.035"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2014.03.034"},{"key":"e_1_2_8_12_1","first-page":"1427","volume":"117","author":"Nuyts R. 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