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However, chemotherapy may inadvertently contribute to the immunosuppression of the tumor microenvironment (TME), inducing the suppression of antitumor immune responses, which can ultimately affect therapeutic efficacy. Chemo\u2010immunotherapy, combining chemotherapy and immunotherapy in cancer treatment, has emerged as a ground\u2010breaking approach to target and eliminate malignant tumors and revolutionize the treatment landscape, offering promising, durable responses for various malignancies. Notably, functional nanomaterials have substantially contributed to chemo\u2010immunotherapy by co\u2010delivering chemo\u2010immunotherapeutic agents and modulating TME. In this review, recent advancements in chemo\u2010immunotherapy are thus summarized to enhance treatment effectiveness, achieved by reversing the immunosuppressive TME (ITME) through the exploitation of immunotherapeutic drugs, or immunoregulatory nanomaterials. The effects of two\u2010way immunomodulation and the causes of immunoaugmentation and suppression during chemotherapy are illustrated. The current strategies of chemo\u2010immunotherapy to surmount the ITME and the functional materials to target and regulate the ITME are discussed and compared. The perspective on tumor immunosuppression reversal strategy is finally proposed.<\/jats:p>","DOI":"10.1002\/smtd.202301005","type":"journal-article","created":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T22:20:26Z","timestamp":1695594026000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Enhancing Cancer Chemo\u2010Immunotherapy: Innovative Approaches for Overcoming Immunosuppression by Functional Nanomaterials"],"prefix":"10.1002","volume":"8","author":[{"given":"Jingjing","family":"Wang","sequence":"first","affiliation":[{"name":"Australian Institute for Bioengineering and Nanotechnology The University of Queensland  Brisbane QLD 4072 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[{"name":"Australian Institute for Bioengineering and Nanotechnology The University of Queensland  Brisbane QLD 4072 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6070-5035","authenticated-orcid":false,"given":"Zhi Ping","family":"Xu","sequence":"additional","affiliation":[{"name":"Australian Institute for Bioengineering and Nanotechnology The University of Queensland  Brisbane QLD 4072 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,24]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1002\/VIW.20200030"},{"key":"e_1_2_8_2_1","first-page":"1","volume":"11","author":"Sun J.","year":"2017","journal-title":"BMC Syst. 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