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Verteporfin (VP) should be an ideal HS\u2010targeted therapeutic drug due to its efficient fibrosis and angiogenesis inhibitory abilities. However, its application is restricted by its side effects such as dose\u2010dependent cytotoxicity on normal cells. Herein, the bioadhesive nanoparticles encapsulated VP (VP\/BNPs) are successfully developed to attenuate the side effects of VP and enhance its HS inhibition effects by limiting VP releasing slowly and stably in the lesion site but not diffusing easily to normal tissues. VP\/BNPs displayed significant inhibition on the proliferation, migration, collagen deposition, and vessel formation of human hypertrophic scar fibroblasts (HSFBs) and dermal vascular endothelial cells (HDVECs). In a rat tail HS model, VP\/BNPs treated HS exhibits dramatic scar repression with almost no side effects compared with free VP or VP\u2010loaded non\u2010bioadhesive nanoparticles (VP\/NNPs) administration. Further immunofluorescence analysis on scar tissue serial sections validated VP\/BNPs effectively inhibited the collagen deposition and angiogenesis by firmly confined in the scar tissue and persistently releasing VP targeted to nucleus Yes\u2010associated protein (nYAP) of HSFBs and HDVECs. These findings collectively suggest that VP\/BNPs can be a promising and technically advantageous agent for HS therapies.<\/jats:p>","DOI":"10.1002\/smtd.202301295","type":"journal-article","created":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T21:56:20Z","timestamp":1702418180000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Verteporfin\u2010Loaded Bioadhesive Nanoparticles for the Prevention of Hypertrophic Scar"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3905-0454","authenticated-orcid":false,"given":"Peng","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Burn and Wound Repair Surgery The First Affiliated Hospital of Sun Yat\u2010senUniversity  No.58, Zhongshan 2nd Road Guangzhou 510080 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