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The pathogenesis of MI unfolds as a progressive process encompassing three pivotal phases: inflammation, proliferation, and remodeling. Smart stimulus\u2010responsive hydrogels have garnered considerable attention for their capacity to deliver therapeutic drugs precisely and controllably at the MI site. Here, a smart stimulus\u2010responsive hydrogel with a dual\u2010crosslinked network structure is designed, which enables the precise and controlled release of therapeutic drugs in different pathological stages for the treatment of MI. The hydrogel can rapidly release curcumin (Cur)\u00a0in the inflammatory phase of MI to exert anti\u2010apoptotic\/anti\u2010inflammatory effects. Recombinant humanized collagen type III (rhCol III) is loaded in the hydrogel and released as the hydrogel swelled\/degraded during the proliferative phase to promote neovascularization. RepSox (a selective TGF\u2010\u03b2 inhibitor) releases from Pluronic F\u2010127 grafted with aldehyde nanoparticles (PF127\u2010CHO@RepSox NPs) in the remodeling phase to against fibrosis. The results in vitro and in vivo suggest that the hydrogel improves cardiac function and alleviates cardiac remodeling by suppressing inflammation and apoptosis, promoting neovascularization, and inhibiting myocardial fibrosis. A whole\u2010course\u2010repair system, leveraging stimulus\u2010responsive multifunctional hydrogels, demonstrates notable effectiveness in enhancing post\u2010MI cardiac function and facilitating the restoration of damaged myocardial tissue.<\/jats:p>","DOI":"10.1002\/smtd.202400121","type":"journal-article","created":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T06:48:50Z","timestamp":1719298130000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["A Whole\u2010Course\u2010Repair System Based on Stimulus\u2010Responsive Multifunctional Hydrogels for Myocardial Tissue Regeneration"],"prefix":"10.1002","volume":"8","author":[{"given":"Wenqi","family":"Liu","sequence":"first","affiliation":[{"name":"National Engineering Research Center for Biomaterials College of Biomedical Engineering Chuanda\u2010Jinbo Joint Research Center Med\u2010X Center for Materials Sichuan University  Chengdu 610064 P. R. 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China"},{"name":"Department of Cardiology General Hospital of Northern Theater Command Shenyang  Shenyang 110016 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yang","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Biomaterials College of Biomedical Engineering Chuanda\u2010Jinbo Joint Research Center Med\u2010X Center for Materials Sichuan University  Chengdu 610064 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Hu","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Biomaterials College of Biomedical Engineering Chuanda\u2010Jinbo Joint Research Center Med\u2010X Center for Materials Sichuan University  Chengdu 610064 P. R. 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