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Herein, an intelligent nanotheranostic platform (denoted as TPZ@Cu\u2010SnS\n                    <jats:sub>2\u2010x<\/jats:sub>\n                    \/PLL) for tumor microenvironment (TME) and near\u2010infrared light (NIR) activated tumor\u2010specific therapy is constructed. Copper (Cu) doping and the resulting sulfur vacancies can not only improve the response range of visible light but also improve the separation efficiency of photogenerated carriers and increase the carrier density, resulting in the ideal photothermal and photodynamic performance. Density functional theory calculations revealed that the introduction of Cu and resulting sulfur vacancies can induce electron redistribution, achieving favorable photogenerated electrons. After entering cells through endocytosis, the TPZ@Cu\u2010SnS\n                    <jats:sub>2\u2010x<\/jats:sub>\n                    \/PLL nanocomposites show the pH responsivity property for the release of the TPZ selectively within the acidic TME, and the released Cu\n                    <jats:sup>2+<\/jats:sup>\n                    can first interact with local glutathione (GSH) to deplete GSH with the production of Cu\n                    <jats:sup>+<\/jats:sup>\n                    . Subsequently, the Cu\n                    <jats:sup>+<\/jats:sup>\n                    \u2010mediated Fenton\u2010like reaction can decompose local\u00a0hydrogen peroxide into hydroxyl radicals, which can also be promoted by hyperthermia derived from the photothermal effect for tumor cell apoptosis. The integration of photoacoustic\/computed tomography imaging\u2010guided NIR phototherapy, TPZ\u2010induced chemotherapy, and GSH\u2010elimination\/hyperthermia enhanced chemodynamic therapy results in synergistic therapeutic outcomes without obvious systemic toxicity in vivo.\n                  <\/jats:p>","DOI":"10.1002\/smtd.202400125","type":"journal-article","created":{"date-parts":[[2024,3,10]],"date-time":"2024-03-10T16:11:30Z","timestamp":1710087090000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Defect\u2010Engineered Tin Disulfide Nanocarriers as \u201cPrecision\u2010Guided Projectile\u201d for Intensive Synergistic Therapy"],"prefix":"10.1002","volume":"8","author":[{"given":"Yanlin","family":"Zhu","sequence":"first","affiliation":[{"name":"Key Laboratory of Superlight Materials and Surface Technology Ministry of Education College of Materials Science and Chemical Engineering Harbin Engineering University  Harbin 150001 P. 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