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Due to the complexity of the brain injury mechanisms following ICH, there are currently no effective treatments to significantly improve patient functional outcomes. Curcumin, as a potential therapeutic agent for ICH, is limited by its poor water solubility and oral bioavailability. In this study, mPEG\u2010PCL is used to encapsulate curcumin, forming curcumin nanoparticles, and utilized the intranasal administration route to directly deliver curcumin nanoparticles from the nasal cavity to the brain. By inhibiting pro\u2010inflammatory neuroinflammation of microglia following ICH in mice, reprogramming pro\u2010inflammatory microglia toward an anti\u2010inflammatory function, and consequently reducing neuronal inflammatory death and hematoma volume, this approach improved blood\u2010brain barrier damage in ICH mice and promoted the recovery of neurological function post\u2010stroke. 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