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The essential role of inflammation in the development of OA has been recognized recently. Accordingly, simultaneous regulation of local inflammation and tissue degeneration is proposed as a promising therapeutic strategy. Herein, multifunctional biomimetic apoptotic nanovesicles (Apo\u2010NVs) are constructed with plasma membrane derived from apoptotic T cells. The anti\u2010inflammatory microRNA\u2010124 is further encapsulated into Apo\u2010NVs in the hope of achieving an enhanced immunomodulatory effect. It is found that apoptotic nanovesicles, including Apo\u2010NVs and Apo\u2010NVs\u2010miR\u2010124, both efficiently promote the M2 repolarization of M1 macrophages and inhibit the degenerative phenotype of chondrocytes. Further in vivo studies show that Apo\u2010NVs and Apo\u2010NVs\u2010miR\u2010124 alleviate synovial inflammation and protect cartilage tissue from degeneration in OA mice. The study highlights the potential of Apo\u2010NVs in treating OA and other inflammation\u2010related diseases.<\/jats:p>","DOI":"10.1002\/smtd.202400660","type":"journal-article","created":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T09:00:17Z","timestamp":1721638817000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Plasma Membrane\u2010Derived Biomimetic Apoptotic Nanovesicles Targeting Inflammation and Cartilage Degeneration for Osteoarthritis"],"prefix":"10.1002","volume":"9","author":[{"given":"Zongyi","family":"Li","sequence":"first","affiliation":[{"name":"School of Materials Science and Engineering South China University of Technology  Guangzhou 510641 China"},{"name":"National Engineering Research Center for Tissue Restoration and Reconstruction and Innovation Center for Tissue Restoration and Reconstruction  Guangzhou 510006 China"},{"name":"Laboratory of Biomedical Engineering of Guangdong 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