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However, the trade\u2010off between high loading efficiency and high catalytic activity remains challenging because high concentrations of nanoparticles tend to cause the misjoining and collapse of the MOFs. Herein, a facile strategy is reported to encapsulate high concentrations of platinum (Pt) nanoparticles into zeolitic imidazolate framework\u20108 (ZIF\u20108) using polydopamine (PDA) as a support for Pt@ZIF\u20108 and as a flexible scaffold for further immobilization of Pt nanoparticles. The resulting composite (Pt@ZIF\u20108@PDA@Pt) exhibits ultrahigh Pt nanoparticle loading efficiency, exceptional catalytic activity, stability, and a bright colorimetric signal. Following integration with lateral flow immunoassay (LFIA), the detection limits for pre\u2010 and post\u2010catalysis detection of B\u2010type natriuretic peptide (NT\u2010proBNP) are 0.18 and 0.015\u00a0ng mL<jats:sup>\u22121<\/jats:sup>, respectively, representing a 6\u2010fold and 70\u2010fold improvement compared to gold nanoparticle\u2010based LFIA. Moreover, Pt@ZIF\u20108@PDA@Pt\u2010based LFIA achieves 100% diagnostic sensitivity for NT\u2010proBNP in a cohort of 184 clinical samples.<\/jats:p>","DOI":"10.1002\/smtd.202400738","type":"journal-article","created":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T13:34:22Z","timestamp":1722432862000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Flexible Scaffold Modulation of Spatial Structure and Function of Hierarchically Porous Nanoparticle@ZIF\u20108 Composites to Enhance Field Deployable Disease Diagnostics"],"prefix":"10.1002","volume":"9","author":[{"given":"Chunyang","family":"Li","sequence":"first","affiliation":[{"name":"Department of Cardiology The First Affiliated Hospital of Chongqing Medical University Chongqing Medical University  Chongqing 400016 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