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To address these issues, this work proposed a platelets (PLTs) based hydrogel delivery system for immuno\u2010chemotherapy, (IL\u201012+NP<jats:sub>D<\/jats:sub>\u2010PLT)@dAlg. To utilize the targeting ability of PLTs toward tumor cells and maintain the activity of PLTs, doxorubicin\u2010loaded nanoparticles (NP<jats:sub>D<\/jats:sub>) were attached on the surface of PTLs (NP<jats:sub>D<\/jats:sub>\u2010PLT). Under the conditions of the post\u2010surgical tumor microenvironment (TME), these PTLs responsively released small\u2010sized drug\u2010loaded vesicles (NP<jats:sub>D<\/jats:sub>\u2010PMP) trapping metastatic tumor cells, inducing immunogenic cell death (ICD) of tumor cells. Additionally, immunomodulatory drugs, IL\u201012, was combined in the hydrogel to synergistically activate CD8<jats:sup>+<\/jats:sup> T cells within the body and induce the polarization of tumor\u2010associated macrophages (TAMs) toward M1 cells, thereby improving the immunosuppressive microenvironment post\u2010surgery. In a 4T1 tumor recurrence and metastasis mouse model, (IL\u201012+NP<jats:sub>D<\/jats:sub>\u2010PLT)@dAlg has shown effective inhibition of tumor recurrence and metastasis, reversing the tumor immune environment, and prolonging survival.<\/jats:p>","DOI":"10.1002\/smtd.202401425","type":"journal-article","created":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T01:34:35Z","timestamp":1732239275000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Platelet Activation\u2010Induced In Situ Trapping Metastatic Tumor Cells Strategy for Post\u2010Surgery Tumor Recurrence Immunochemotherapy"],"prefix":"10.1002","volume":"9","author":[{"given":"Tiantian","family":"Zhang","sequence":"first","affiliation":[{"name":"Tongji School of Pharmacy Huazhong University of Science and Technology  Wuhan 430030 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