{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:34:49Z","timestamp":1787240089083,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T00:00:00Z","timestamp":1741219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T00:00:00Z","timestamp":1741219200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["12275169"],"award-info":[{"award-number":["12275169"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["11905123"],"award-info":[{"award-number":["11905123"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971740"],"award-info":[{"award-number":["81971740"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31671011"],"award-info":[{"award-number":["31671011"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small Methods"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Precision phototherapy requires tight control over several therapeutic steps, which traditional methods often struggle to achieve. Here, this study reports an orthogonal trichromatic upconversion nanoparticle with a rather simple nanoarchitecture, NaErF\n                    <jats:sub>4<\/jats:sub>\n                    @NaYbF\n                    <jats:sub>4<\/jats:sub>\n                    @NaYbF\n                    <jats:sub>4<\/jats:sub>\n                    :Nd@NaYF\n                    <jats:sub>4<\/jats:sub>\n                    :Yb,Tm. Unlike conventional designs that rely on multiple activators and complicated multi\u2010shelled structures (up to six nanoshells), the reported triple\u2010shelled UCNPs utilize only two activator ions (Er\n                    <jats:sup>3<\/jats:sup>\n                    \u207a and Tm\n                    <jats:sup>3<\/jats:sup>\n                    \u207a) but still enables to release red, green, and blue colors in response to three different NIR light excitations, thus significantly reducing structural complexity and synthetic workload. Integrating these UCNPs with photosensitizers and nitric oxide (NO) donors further achieve to a precision photodynamic therapy, which allows for step\u2010wise control throughout the entire PDT process by independent activation of bioimaging, photochemical internalization, respiration prohibition via NO release, and ROS generation via specific light illuminations. Both in vitro and in vivo results demonstrate high efficiency of presented methodology, highlighting its great potential for NIR light\u2010activated precision phototherapy.\n                  <\/jats:p>","DOI":"10.1002\/smtd.202401742","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T05:38:01Z","timestamp":1741757881000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Achieving Precision Phototherapy from Start to Finish: Integrating Endosomal Escape, Respiration Inhibition, and ROS Release in a Single Upconversion Nanoparticle"],"prefix":"10.1002","volume":"9","author":[{"given":"Jing","family":"Wang","sequence":"first","affiliation":[{"name":"School of Environmental and Chemical Engineering Shanghai University  Shanghai 200444 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hejingying","family":"Niu","sequence":"additional","affiliation":[{"name":"School of Environmental and Chemical Engineering Shanghai University  Shanghai 200444 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huadong","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Environmental and Chemical Engineering Shanghai University  Shanghai 200444 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Yuan","sequence":"additional","affiliation":[{"name":"School of Environmental and Chemical Engineering Shanghai University  Shanghai 200444 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Zheng","sequence":"additional","affiliation":[{"name":"School of Environmental and Chemical Engineering Shanghai University  Shanghai 200444 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tonghan","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Environmental and Chemical Engineering Shanghai University  Shanghai 200444 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihan","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Environmental and Chemical Engineering Shanghai University  Shanghai 200444 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinliang","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Environmental and Chemical Engineering Shanghai University  Shanghai 200444 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailong","family":"Che","sequence":"additional","affiliation":[{"name":"School of Environmental and Chemical Engineering Shanghai University  Shanghai 200444 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering City University of Hong Kong  Hong Kong SAR 999077 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2815-5197","authenticated-orcid":false,"given":"Xiaohui","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Environmental and Chemical Engineering Shanghai University  Shanghai 200444 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,6]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201700609"},{"key":"e_1_2_8_2_1","volume":"6","author":"Zhu X.","year":"2019","journal-title":"Adv. Sci."},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.200801635"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201107919"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b01458"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202211402"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201604671"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201902185"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b04200"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202306684"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9NR10453D"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00604-022-05218-4"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.bioconjchem.8b00732"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2612"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1367"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8CS00304A"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202004552"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.3c00397"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.1c01510"},{"key":"e_1_2_8_20_1","first-page":"1","volume":"11","author":"Liu Y.","year":"2021","journal-title":"Nanomaterials"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.bioconjchem.0c00046"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b11972"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsanm.3c00998"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10254"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn402601d"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jallcom.2007.12.091"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.0c01539"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-32498-4"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceramint.2017.02.041"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jre.2022.01.020"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jlumin.2022.119037"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1002-0721(16)60107-2"},{"key":"e_1_2_8_33_1","first-page":"1784","volume":"13","author":"Yu W.","year":"2019","journal-title":"ACS Nano"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1088\/0957-4484\/19\/34\/345606"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/om00134a024"}],"container-title":["Small Methods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smtd.202401742","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/smtd.202401742","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smtd.202401742","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T09:07:15Z","timestamp":1774343235000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/smtd.202401742"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,6]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1002\/smtd.202401742"],"URL":"https:\/\/doi.org\/10.1002\/smtd.202401742","archive":["Portico"],"relation":{},"ISSN":["2366-9608","2366-9608"],"issn-type":[{"value":"2366-9608","type":"print"},{"value":"2366-9608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,6]]},"assertion":[{"value":"2024-10-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2401742"}}