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Cold atmospheric plasma (CAP) offers a tumor\u2010selective ablation strategy but suffers from limited tissue penetration. To overcome this, the FlexiPlasma microcatheter (FPM) is developed, integrating flexible non\u2010metallic microtubes and ring\u2010shaped electrodes for precise CAP delivery to deep tumors. The optimized FPM\u2010generated CAP eliminates cytotoxic UV and ozone while inducing tumor\u2010specific pyroptosis via a ROS\/Caspase\u20108\/GSDMC pathway. Gasdermin\u2010C (GSDMC) is highly expressed in liver tumors but absent in normal tissues, ensuring selective targeting with minimal inflammation. FPM is combined with embolic material (EM), PPP@CD hydrogel, enhancing injectability, tumor embolization, and sustained drug release. This FPM\u2010EM strategy potentiates antitumor immunity, particularly CD4+ and CD8+ T\u2010cell responses. These findings establish FPM\u2010EM as a safe, effective, and minimally invasive therapy for HCC, revealing a non\u2010inflammatory pyroptosis mechanism and broadening the potential of CAP\u2010based cancer treatments. The FPM\u2010EM combination offers promising new therapeutic options for HCC, addressing the limitations of TACE. Furthermore, the FPM\u2010EM platform can be extended to the interventional therapy of other tumors and adapted to incorporate various drugs and nano\u2010\/micro\u2010materials, highlighting the strong potential for future clinical translation.<\/jats:p>","DOI":"10.1002\/smtd.202500231","type":"journal-article","created":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T02:15:34Z","timestamp":1745633734000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["FlexiPlasma Microcatheter\u2013Embolic Material (FPM\u2010EM) Platform: A Non\u2010Inflammatory Pyroptosis Strategy for Precision Hepatocellular Carcinoma Therapy"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-2213-0481","authenticated-orcid":false,"given":"Changhong","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology Innovation Center for Cell Biology School of Life 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